ArticleScientific reports2018
Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- [Research progress on genetic effects of the asymmetry of human brain structure revealed by magnetic resonance imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Pooled it
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- Single-nucleus profiling decoding the subcortical visual pathway evolution of vertebrates.iScience · 2025Article
- Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment-resistant major depressive disorder.Psychiatry and clinical neurosciences · 2025Article
- An evolutionary timeline of the oxytocin signaling pathway.Communications biology · 2024Article
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- A multiscale characterization of cortical shape asymmetries in early psychosis.Brain communications · 2024Article
- A deep phenotyping approach to assess the association of handedness, early life factors and mental health.Scientific reports · 2023Article
- Normal reference values for magnetic resonance imaging measurements of the fetal internal jugular veins in middle and late pregnancy.Pediatric radiology · 2023Article
- Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project.Translational psychiatry · 2023Article
- Enlarged choroid plexus related to cortical atrophy in multiple sclerosis.European radiology · 2023Article
- Article
- Changes in and asymmetry of the proteome in the human fetal frontal lobe during early development.Communications biology · 2022Article
- Light-induced asymmetries in embryonic retinal gene expression are mediated by the vascular system and extracellular matrix.Scientific reports · 2022Article
- A computational model based on corticospinal functional MRI revealed asymmetrically organized motor corticospinal networks in humans.Communications biology · 2022Article
- Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults.Brain structure & function · 2022Article
- Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization.Molecular psychiatry · 2021Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Left-right laterality is an important aspect of human -and in fact all vertebrate- brain organization for which the genetic basis is poorly understood. Using RNA sequencing data we contrasted gene expression in left- and right-sided samples from several structures of the anterior central nervous systems of post mortem human embryos and foetuses. While few individual genes stood out as significantly lateralized, most structures showed evidence of laterality of their overall transcriptomic profiles. These left-right differences showed overlap with age-dependent changes in expression, indicating lateralized maturation rates, but not consistently in left-right orientation over all structures. Brain asymmetry may therefore originate in multiple locations, or if there is a single origin, it is earlier than 5 weeks post conception, with structure-specific lateralized processes already underway by this age. This pattern is broadly consistent with the weak correlations reported between various aspects of adult brain laterality, such as language dominance and handedness.
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Registered trials
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