ArticleScientific reports2018
Evolution shapes the responsiveness of the D-box enhancer element to light and reactive oxygen species in vertebrates.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- D-Box Binding Protein (DBP) as a Circadian Output Regulator: Molecular Mechanisms, Tissue-Specific Functions, and Disease Relevance.International journal of molecular sciences · 2026Review
- 6-4 photolyase differentially modulates transcription in the vertebrate circadian clock.PLoS genetics · 2025Article
- Light-Induced Transcription in Zebrafish Targets Mitochondrial Function and Heme Metabolism.Antioxidants (Basel, Switzerland) · 2025Article
- Light-regulated microRNAs shape dynamic gene expression in the zebrafish circadian clock.PLoS genetics · 2025Article
- Exploring Photoreceptor Gene Expression and Seasonal Physiology in Mediterranean Swordfish (Animals : an open access journal from MDPI · 2024Article
- Heat-inactivated Streptococcus pneumoniae augments circadian clock gene expression in zebrafish cells.Scientific reports · 2024Article
- 3D spheroid culturing of Astyanax mexicanus liver-derived cell lines recapitulates distinct transcriptomic and metabolic states of in vivo tissue environment.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution.Antioxidants (Basel, Switzerland) · 2024Review
- Transcriptomic Analysis of Light-Induced Genes inBiology · 2023Article
- Blind fish have cells that see light.Proceedings. Biological sciences · 2023Article
- Immunity, Infection, and the Zebrafish Clock.Infection and immunity · 2022Review
- Liver-derived cell lines from cavefish Astyanax mexicanus as an in vitro model for studying metabolic adaptation.Scientific reports · 2022Article
- Article
- A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light.Scientific reports · 2021Article
- Photoreceptor Diversification Accompanies the Evolution of Anthozoa.Molecular biology and evolution · 2021Article
- Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair.PLoS genetics · 2021Article
- S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in p53 Deleted Colon Cancer Cells.International journal of molecular sciences · 2020Article
- Diversified regulation of circadian clock gene expression following whole genome duplication.PLoS genetics · 2020Article
- Article
- Post-translational Modifications are Required for Circadian Clock Regulation in Vertebrates.Current genomics · 2019Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock is a highly conserved cell-autonomous mechanism that directs daily rhythms in most aspects of biology. Daily entrainment by environmental signals, notably light, is essential for its function. However, our understanding of the mechanisms and the evolution of photic entrainment remains incomplete. Fish represent attractive models for exploring how light regulates the circadian clock due to the direct light sensitivity of their peripheral clocks. Central to this property is the light induced expression of clock genes that is mediated by D-box enhancer elements. Here, using zebrafish cells, we reveal that the light responsive D-box enhancer serves as a nuclear target for reactive oxygen species (ROS). We demonstrate that exposure to short wavelengths of visible light triggers increases in ROS levels via NADPH oxidase activity. Elevated ROS activates the JNK and p38 MAP kinases and in turn, induces clock gene expression via the D-box. In blind cavefish and mammals, where peripheral clocks are no longer entrained by direct illumination, ROS levels are still increased upon light exposure. However, in these species ROS no longer induces D-box driven clock gene transcription. Thus, during evolution, alterations in ROS-responsive signal transduction pathways underlie fundamental changes in peripheral clock photoentrainment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.