Evidence map›Paper›PMID 30181481›Full record

ArticleInternational journal of molecular sciences2018

Activation of Bone Marrow-Derived Cells Angiotensin (Ang) II Type 1 Receptor by Ang II Promotes Atherosclerotic Plaque Vulnerability.

Maxime Pellegrin, Karima Bouzourène, Jean-François Aubert, Aimable Nahimana, Michel A Duchosal, Lucia Mazzolai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maxime PellegrinDivision of Angiology, Heart and Vessel Department, Lausanne University Hospital, 1011 Lausanne, Switzerland. maxime.pellegrin@chuv.ch.ORCID 0000-0003-4948-976X
Karima BouzourèneDivision of Angiology, Heart and Vessel Department, Lausanne University Hospital, 1011 Lausanne, Switzerland. karima.bouzourene@chuv.ch.
Jean-François AubertDivision of Angiology, Heart and Vessel Department, Lausanne University Hospital, 1011 Lausanne, Switzerland. jfacgp@outlook.com.
Aimable NahimanaService and Central Laboratory of Hematology, LABORATORY and Oncology DepartmentS, Lausanne University Hospital, 1011 Lausanne, Switzerland. aimable.nahimana@chuv.ch.ORCID 0000-0003-4968-3167
Michel A DuchosalService and Central Laboratory of Hematology, LABORATORY and Oncology DepartmentS, Lausanne University Hospital, 1011 Lausanne, Switzerland. michel.duchosal@chuv.ch.
Lucia MazzolaiDivision of Angiology, Heart and Vessel Department, Lausanne University Hospital, 1011 Lausanne, Switzerland. lucia.mazzolai@chuv.ch.
University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiotensin (Ang) II triggers vulnerable atherosclerotic plaque development. Bone marrow (BM)-derived cells are key players in atherogenesis but whether Ang II induces plaque vulnerability directly through Ang II type 1 receptor (AT1R) activation on these cells remains to be clarified. In the present study, we investigated whether a lack of AT1R on BM-derived cells might affect Ang II-mediated vulnerable plaque development. The 2-kidney, 1-clip (2K1C) model (Ang II-dependent mouse model of advanced atherosclerosis and vulnerable plaques) was generated in ApoE

Indexed as

AngiotensinsAnimalsApolipoproteins EBone Marrow CellsBone Marrow TransplantationCytokinesDisease Models, AnimalGene Expression RegulationGene Knockdown TechniquesHumansLipid MetabolismLiverMicePlaque, AtheroscleroticReceptor, Angiotensin, Type 1Agtr1a protein, mouseAngiotensinsApolipoproteins ECytokinesReceptor, Angiotensin, Type 12-kidney, 1-clip ApoE−/− miceAngiotensin IIatherosclerosisbone marrow transplantationinflammationvulnerable plaque

Identifiers

PMID30181481
PMCPMC6163751
OpenAlexW2890646606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.