Evidence map›Paper›PMID 30181442›Full record

ArticleMolecules (Basel, Switzerland)2018

Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1

Magda Kondej, Agata Bartyzel, Monika Pitucha, Tomasz M Wróbel, Andrea G Silva, Dariusz Matosiuk, Marián Castro, Agnieszka A Kaczor

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Biomolecules · 2020
    Article
  5. Article
  6. The Universal 3D QSAR Model for Dopamine DInternational journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Magda KondejDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodźki St., PL-20093 Lublin, Poland. magda.kondej@onet.pl.
Agata BartyzelDepartment of General and Coordination Chemistry, Maria Curie-Skłodowska University, M. Curie-Skłodowskiej Sq. 2, PL-20031 Lublin, Poland. agata.bartyzel@poczta.umcs.lublin.pl.ORCID 0000-0003-3765-6997
Monika PituchaIndependent Radiopharmacy Unit, Department of Organic Chemistry, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodźki St., PL-20093 Lublin, Poland. monika.pitucha@umlub.pl.
Tomasz M WróbelDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodźki St., PL-20093 Lublin, Poland. tomasz.wrobel@umlub.pl.ORCID 0000-0002-0313-2522
Andrea G SilvaDepartment of Pharmacology, Universidade de Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Avda de Barcelona, E-15782 Santiago de Compostela, Spain. andrea.garcia.silva@rai.usc.es.
Dariusz MatosiukDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodźki St., PL-20093 Lublin, Poland. dariusz.matosiuk@umlub.pl.
Marián CastroDepartment of Pharmacology, Universidade de Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Avda de Barcelona, E-15782 Santiago de Compostela, Spain. marian.castro@usc.es.ORCID 0000-0002-4732-1966
Agnieszka A KaczorDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodźki St., PL-20093 Lublin, Poland. agnieszka.kaczor@umlub.pl.

Funding

Narodowe Centrum Nauki 2017/27/B/NZ7/01767
6 · The paper itself

Abstract

Compound D2AAK1_3 was designed as a modification of the lead structure D2AAK1 (an in vivo active multi-target compound with nanomolar affinity to a number of aminergic GPCRs) and synthesized in the reaction of 5-ethoxyindole and 1-benzyl-4-piperidone. This compound has an affinity to the human dopamine D₂ receptor with K

Indexed as

TemperatureBinding, CompetitiveCalorimetry, Differential ScanningCrystallography, X-RayHumansHydrogen BondingIndolesLigandsMolecular ConformationMolecular Docking SimulationPyrrolidinesReceptors, Dopamine D2Spectroscopy, Fourier Transform InfraredThermogravimetry3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indoleindoleIndolesLigandsPyrrolidinesReceptors, Dopamine D2dopamine D2 receptordopamine D2 receptor antagonistmolecular modelingthermal studiesX-ray studies

Identifiers

PMID30181442
PMCPMC6225423

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.