Evidence map›Paper›PMID 30181395›Full record

ArticleMolecular and cellular biology2018

Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling.

Daniel Triner, Cristina Castillo, Joe B Hakim, Xiang Xue, Joel K Greenson, Gabriel Nuñez, Grace Y Chen, Justin A Colacino, Yatrik M Shah

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 65 citations in OpenAlex.

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  14. Targeting Myc-driven stress addiction in colorectal cancer.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Daniel TrinerDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Cristina CastilloDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Joe B HakimDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Xiang XueDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Joel K GreensonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Gabriel NuñezDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Grace Y ChenInternal Medicine Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Justin A ColacinoDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Yatrik M ShahDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA shahy@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Translational Research in GI CancerP50CA130810 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, DEAN E. · 2010 to 2016
$11.8M
Control of iron absorption by intestinal HIF2 in iron and hematological disordersR01DK095201 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2012 to 2025
$5.7M
The role of HIF2alpha in colon carcinogenesisR01CA148828 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2010 to 2025
$5.2M
Diversity SupplementR01ES028802 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 2018 to 2026
$4.8M
MAZ as a Novel Regulator of STAT3 Signaling in Colon CancerF30CA213664 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRINER, DANIEL AUGUSTUS · 2017 to 2018
$43k
NCI NIH HHS F30 CA213664NCI NIH HHS P50 CA130810NCI NIH HHS R01 CA148828NIDDK NIH HHS R01 DK095201NIEHS NIH HHS R01 ES028802
6 · The paper itself

Abstract

Myc-associated zinc finger (MAZ) is a transcription factor highly upregulated in chronic inflammatory disease and several human cancers. In the present study, we found that MAZ protein is highly expressed in human ulcerative colitis and colon cancer. However, the precise role for MAZ in the progression of colitis and colon cancer is not well defined. To determine the function of MAZ, a novel mouse model of intestinal epithelial cell-specific MAZ overexpression was generated. Expression of MAZ in intestinal epithelial cells was sufficient to enhance inflammatory injury in two complementary models of colitis. Moreover, MAZ expression increased tumorigenesis in an

Indexed as

AnimalsCarcinogenesisCell Line, TumorCell ProliferationColitisColonic NeoplasmsCytokinesDisease Models, AnimalDNA-Binding ProteinsEpithelial CellsHCT116 CellsHT29 CellsHumansInflammationMiceMice, Inbred C57BLc-MYC-associated zinc finger proteinCytokinesDNA-Binding ProteinsSTAT3 protein, humanSTAT3 Transcription FactorTranscription Factorscolitiscolon cancerinflammationMAZSTAT3

Identifiers

PMID30181395
PMCPMC6206459
OpenAlexW2891930398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.