Evidence map›Paper›PMID 30181394›Full record

ArticleMolecular and cellular biology2018

Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells.

Guido H Wabnitz, Henning Kirchgessner, Beate Jahraus, Ludmila Umansky, Shirish Shenolikar, Yvonne Samstag

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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  7. Effect ofAnalytical cellular pathology (Amsterdam) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Guido H WabnitzInstitute of Immunology, Ruprecht Karls University, Heidelberg, Germany guido.wabnitz@immu.uni-heidelberg.de.
Henning KirchgessnerInstitute of Immunology, Ruprecht Karls University, Heidelberg, Germany.
Beate JahrausInstitute of Immunology, Ruprecht Karls University, Heidelberg, Germany.
Ludmila UmanskyInstitute of Immunology, Ruprecht Karls University, Heidelberg, Germany.
Shirish ShenolikarDuke-NUS Medical School Singapore, Singapore, Singapore.
Yvonne SamstagInstitute of Immunology, Ruprecht Karls University, Heidelberg, Germany.
Heidelberg University · DEDuke-NUS Medical School · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While several protein serine/threonine kinases control cytokine production by T cells, the roles of serine/threonine phosphatases are largely unexplored. Here, we analyzed the involvement of protein phosphatase 1α (PP1α) in cytokine synthesis following costimulation of primary human T cells. Small interfering RNA (siRNA)-mediated knockdown of PP1α (PP1

Indexed as

Actin Depolymerizing FactorsAnti-Inflammatory AgentsCD4-Positive T-LymphocytesCell NucleusCells, CulturedCytokinesHumansImmunityInflammationInterleukin-10NF-kappa BProtein Phosphatase 1Protein TransportTh2 CellsActin Depolymerizing FactorsAnti-Inflammatory AgentsCytokinesIL10 protein, humanInterleukin-10NF-kappa BProtein Phosphatase 1cytokinesphosphataseT-cell activation

Identifiers

PMID30181394
PMCPMC6206454
OpenAlexW2890317645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.