Evidence map›Paper›PMID 30181389›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Synergistic Interaction of

Csilla Sipeky, Ping Gao, Qin Zhang, Liang Wang, Otto Ettala, Kirsi M Talala, Teuvo L J Tammela, Anssi Auvinen, Fredrik Wiklund, Gong-Hong Wei and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  16. HOXB13 and TFF3 can contribute to the prognostic stratification of prostate adenocarcinoma.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

Csilla Sipeky *Institute of Biomedicine, University of Turku, Turku, Finland.
Ping Gao *Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Qin ZhangBiocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Liang WangDepartment of Pathology, MCW Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-9364-8572
Otto EttalaDepartment of Urology, Turku University Hospital, Turku, Finland.ORCID 0000-0003-1011-4602
Kirsi M TalalaFinnish Cancer Registry, Mass Screening Registry, Helsinki, Finland.
Teuvo L J TammelaDepartment of Urology, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland.
Anssi AuvinenDepartment of Epidemiology, School of Health Sciences, University of Tampere, Tampere, Finland.ORCID 0000-0003-1125-4818
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-4623-0544
Gong-Hong WeiBiocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland. Johanna.Schleutker@utu.fi Gonghong.wei@oulu.fi.
Johanna SchleutkerInstitute of Biomedicine, University of Turku, Turku, Finland. Johanna.Schleutker@utu.fi Gonghong.wei@oulu.fi.
University of Oulu · FIUniversity of Turku · FIFinnish Cancer Registry · FIKarolinska Institutet · SEMedical College of Wisconsin · USTampere University · FITampere University Hospital · FITurku University Hospital · FI

Funding

Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Cell free nucleic acid-based biomarkers in advanced prostate cancerR01CA212097 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI KOHLI, MANISH, WANG, LIANG · 2017 to 2022
$3.1M
Genetic determinants of gene expression phenotypes in aggressive prostate cancerR01CA157881 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI WANG, LIANG · 2011 to 2016
$2.9M
Imputation-based approach to identify low frequency variants in prostate cancerU01CA188392 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SCHUMACHER, FREDRICK RAY · 2014 to 2016
$1.9M
NCI NIH HHS R01 CA157881NCI NIH HHS R01 CA212097NCI NIH HHS U01 CA188392NCI NIH HHS U19 CA148537NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008I
6 · The paper itself

Abstract

purposeDistinguishing aggressive prostate cancer from indolent disease improves personalized treatment. Although only few genetic variants are known to predispose to aggressive prostate cancer, synergistic interactions of EXPERIMENTAL

designGenotyping was done in Finnish discovery cohort (

resultsInterplay of

conclusionsSimultaneous presence of

Indexed as

Epistasis, GeneticGenetic Association StudiesGenetic Predisposition to DiseaseAllelesAutoantigensDisease ProgressionGene Expression Regulation, NeoplasticGenotypeGerm-Line MutationHomeodomain ProteinsHumansIntracellular Signaling Peptides and ProteinsKaplan-Meier EstimateMaleMembrane ProteinsNeoplasm GradingAutoantigensCIP2A protein, humanHomeodomain ProteinsHOXB13 protein, humanIntracellular Signaling Peptides and ProteinsMembrane Proteins

Identifiers

PMID30181389
PMCPMC6719560
OpenAlexW2893780367

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.