Evidence map›Paper›PMID 30181372›Full record

ArticleAntimicrobial agents and chemotherapy2018

Bifunctional Enzyme SpoT Is Involved in Biofilm Formation of Helicobacter pylori with Multidrug Resistance by Upregulating Efflux Pump Hp1174 (

Xiaoran Ge, Yuying Cai, Zhenghong Chen, Sizhe Gao, Xiwen Geng, Ya Li, Yan Li, Jihui Jia, Yundong Sun

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Monoterpene Indole Alkaloids with Antimicrobial Activity AgainstInternational journal of molecular sciences · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Overcoming antibiotic-resistantWorld journal of gastroenterology · 2025
    Review
  7. Article
  8. Nanomaterials: A Prospective Strategy for Biofilm-FormingInternational journal of nanomedicine · 2025
    Review
  9. Diseases (Basel, Switzerland) · 2024
    Review
  10. International journal of molecular sciences · 2024
    Review
  11. Review
  12. Article
  13. Role of bacterial multidrug efflux pumps during infection.World journal of microbiology & biotechnology · 2024
    Review
  14. Article
  15. Antibiotic Resistance ofJournal of Korean medical science · 2024
    Review
  16. Frontiers in cellular and infection microbiology · 2024
    Article
  17. Novel therapeutic regimens againstFrontiers in microbiology · 2024
    Review
  18. Biofilm ofAntibiotics (Basel, Switzerland) · 2023
    Review
  19. Global Antimicrobial Resistance Gene Study ofAntibiotics (Basel, Switzerland) · 2023
    Article
  20. SpoT-mediated NapA upregulation promotes oxidative stress-inducedAntimicrobial agents and chemotherapy · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaoran Ge *Department of Microbiology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Basic Medicine, Jinan, Shandong, People's Republic of China.
Yuying Cai *Department of Microbiology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Basic Medicine, Jinan, Shandong, People's Republic of China.
Zhenghong ChenDepartment of Microbiology, Guiyang Medical University, Guiyang, Guizhou, People's Republic of China.ORCID 0000-0002-2944-6001
Sizhe GaoDepartment of Microbiology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Basic Medicine, Jinan, Shandong, People's Republic of China.
Xiwen GengDepartment of Microbiology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Basic Medicine, Jinan, Shandong, People's Republic of China.
Ya LiDepartment of Microbiology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Basic Medicine, Jinan, Shandong, People's Republic of China.
Yan LiSchool of Control Science and Engineering, Shandong University, Jinan, People's Republic of China.
Jihui JiaDepartment of Microbiology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Basic Medicine, Jinan, Shandong, People's Republic of China.
Yundong SunDepartment of Microbiology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Basic Medicine, Jinan, Shandong, People's Republic of China syd@sdu.edu.cn.
Shandong University · CNGuiyang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The drug resistance of

Indexed as

AnimalsAnti-Bacterial AgentsBacterial ProteinsBiofilmsDrug Resistance, Multiple, BacterialGuanosine PentaphosphateHelicobacter InfectionsHelicobacter pyloriHumansMicrobial Sensitivity TestsSheepTranscriptional ActivationUp-RegulationAnti-Bacterial AgentsBacterial ProteinsGuanosine Pentaphosphateantibiotic resistancebiofilmefflux pumpGluPHelicobacter pyloriSpoT

Identifiers

PMID30181372
PMCPMC6201075
OpenAlexW2952706207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.