Evidence map›Paper›PMID 30181371›Full record

ArticleAntimicrobial agents and chemotherapy2018

The Small-Compound Inhibitor K22 Displays Broad Antiviral Activity against Different Members of the Family Flaviviridae and Offers Potential as a Panviral Inhibitor.

Obdulio García-Nicolás, Philip V'kovski, Nathalie J Vielle, Nadine Ebert, Roland Züst, Jasmine Portmann, Hanspeter Stalder, Véronique Gaschen, Gabrielle Vieyres, Michael Stoffel and 8 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Obdulio García-Nicolás *Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Philip V'kovski *Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Nathalie J VielleInstitute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Nadine EbertInstitute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Roland ZüstSpiez Laboratory, Spiez, Switzerland.
Jasmine PortmannInstitute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Hanspeter StalderInstitute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Véronique GaschenDivision of Veterinary Anatomy, Department of Clinical Research, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Gabrielle VieyresInstitute for Experimental Virology, Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.
Michael StoffelDivision of Veterinary Anatomy, Department of Clinical Research, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Matthias SchweizerInstitute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.ORCID 0000-0002-8616-0640
Artur SummerfieldInstitute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Olivier EnglerSpiez Laboratory, Spiez, Switzerland.
Thomas PietschmannInstitute for Experimental Virology, Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany.ORCID 0000-0001-6789-4422
Daniel TodtDepartment of Molecular and Medical Virology, Ruhr-University Bochum, Bochum, Germany.
Marco P AlvesInstitute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.
Volker Thiel *Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland volker.thiel@vetsuisse.unibe.ch stephanie.pfaender@vetsuisse.unibe.ch.
Stephanie Pfaender *Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland volker.thiel@vetsuisse.unibe.ch stephanie.pfaender@vetsuisse.unibe.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The virus family

Indexed as

AedesAnimalsAntiviral AgentsCell LineCell MembraneChlorocebus aethiopsFlaviviridaeFlaviviridae InfectionsHumansInterferon-alphaRibavirinRNA, ViralVero CellsVirus ReplicationAntiviral AgentsInterferon-alphaRibavirinRNA, ViralantiviralFlaviviridaeflavivirushepacivirusK22panviral inhibitorpestivirus

Identifiers

PMID30181371
PMCPMC6201103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.