Evidence map›Paper›PMID 30181358›Full record

ArticleGenes & development2018

Alternative pre-mRNA splicing switch controls hESC pluripotency and differentiation.

Laura M Agosto, Kristen W Lynch

Open access · diamondAbstract readComment
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Laura M AgostoDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Kristen W LynchDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.
University of Pennsylvania · US

Funding

Signal-Induced Regulation of Alternative RNA ProcessingR35GM118048 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KRISTEN W LYNCH · 2016 to 2026
$6.6M
Splicing and Nuclear Transport of Influenza Virus mRNAR01AI125524 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI COBB, MELANIE H., FONTOURA, BEATRIZ MA · 2016 to 2025
$5.6M
NIAID NIH HHS R01 AI125524NIGMS NIH HHS R35 GM118048
6 · The paper itself

Abstract

Alternative splicing (AS) of pre-mRNAs is a ubiquitous process in mammals that is tightly regulated in a cell type- and cell state-dependent manner. However, the details of how splicing is regulated to impact specific cell fate decisions remains incompletely understood. A study by Yamazaki and colleagues (pp. 1161-1174) in this issue of

Indexed as

Alternative SplicingHeterogeneous-Nuclear Ribonucleoprotein Group F-HAnimalsCadherinsCell DifferentiationHumansRNA PrecursorsCadherinsHeterogeneous-Nuclear Ribonucleoprotein Group F-HRNA Precursorsalternative splicingE2Aheterogeneous nuclear ribonucleoproteinhuman embryonic stem cellT-cell factor 3

Identifiers

PMID30181358
PMCPMC6120719
OpenAlexW2889876439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.