Evidence map›Paper›PMID 30181326›Full record

ArticleSexually transmitted infections2019

Cross-sectional study of urethral exposures at last sexual episode associated with non-gonococcal urethritis among STD clinic patients.

Laura C Chambers, Jennifer L Morgan, M Sylvan Lowens, Tashina S Robinson, Sarah S Romano, Gina L Leipertz, James P Hughes, Matthew R Golden, Christine M Khosropour, David N Fredricks and 1 more

Abstract read
In one paragraph

Article in Sexually transmitted infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
  2. Doxycycline Versus Azithromycin for the Treatment of Rectal Chlamydia in Men Who Have Sex With Men: A Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Trial
  3. Article
  4. Article
  5. Sexually Transmitted Infections in People with Human Immunodeficiency Virus.Infectious disease clinics of North America · 2024
    Review
  6. Article
  7. Urethral Microbiota in Men: Association of Haemophilus influenzae and Mycoplasma penetrans With Nongonococcal Urethritis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Laura C ChambersDepartment of Epidemiology, University of Washington, Seattle, Washington, USA lauracc@uw.edu.ORCID 0000-0003-1802-6578
Jennifer L MorganHIV/STD Program, Public Health - Seattle & King County, Seattle, Washington, USA.
M Sylvan LowensHIV/STD Program, Public Health - Seattle & King County, Seattle, Washington, USA.
Tashina S RobinsonDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Sarah S RomanoDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Gina L LeipertzDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
James P HughesDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Matthew R GoldenDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Christine M KhosropourDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
David N FredricksDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Lisa E ManhartDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
University of Washington · USPublic Health – Seattle & King County · US

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Urethral microbiome and non-gonococcal urethritis in men who have sex with men (MU19AI113173 · NIAID · UNIVERSITY OF WASHINGTON · PI MARRAZZO, JEANNE M · 2014 to 2018
$14.3M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Male urethritis: Novel etiologies and natural historyR01AI110666 · NIAID · UNIVERSITY OF WASHINGTON · PI FREDRICKS, DAVID NEAL, MANHART, LISA E · 2014 to 2018
$3.9M
NCATS NIH HHS TL1 TR002318NCATS NIH HHS UL1 TR002319NIAID NIH HHS R01 AI110666NIAID NIH HHS U19 AI113173
6 · The paper itself

Abstract

objectiveAlthough

methodsWe enrolled STD clinic patients with and without NGU assigned male sex at birth and age ≥16 into a cross-sectional study. NGU was urethral symptoms or visible discharge plus ≥5 polymorphonuclear leucocytes without

resultsBetween 8 August 2014 and 1 November 2017, we enrolled 432 patients, including 183 MSM/TGWSM (118 NGU+, 65 NGU-) and 249 MSW (126 NGU+, 123 NGU-). The mean age was 34; 59% were white. CT and MG were detected in 72 (30%) and 49 (20%) NGU+ participants, respectively. Compared with MSM/TGWSM reporting only non-urethral exposures at last sex, those reporting insertive anal intercourse (IAI) only (adjusted OR (AOR)=4.46, 95% CI 1.09 to 18.19) and IAI with insertive oral sex (IOS) (AOR=7.88, 95% CI 2.67 to 23.26) had higher odds of NGU. MSM/TGWSM reporting IOS only had no significant increased odds (AOR=1.67, 95% CI 0.58 to 4.85). Compared with MSW whose only urethral exposure at last sex was vaginal sex (VS), MSW reporting IOS and VS had similar odds of NGU (OR=0.84, 95% CI 0.50 to 1.41). The results were similar for non-CT/non-MG NGU.

conclusionsAmong MSM/TGWSM, IAI may lead to transmission of yet-unidentified rectal micro-organisms that cause non-CT/non-MG NGU, in addition to transmission of known pathogens. Sites of urethral exposure appear less important for understanding NGU risk among MSW due to minimal variation in behaviour.

Indexed as

Chlamydia trachomatisMycoplasma genitaliumOutpatientsSexual BehaviorTransgender PersonsAdultAgedAmbulatory Care FacilitiesChlamydia InfectionsCross-Sectional StudiesFemaleHumansMaleMiddle AgedMycoplasma InfectionsUrethritischlamydia trachomatisetiologymycoplasma genitaliumsexual behaviorsyndromeurethritis

Identifiers

PMID30181326
PMCPMC7016488
OpenAlexW2890350825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.