Evidence map›Paper›PMID 30181297›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic.

Meredith L Stone, Katherine B Chiappinelli, Huili Li, Lauren M Murphy, Meghan E Travers, Michael J Topper, Dimitrios Mathios, Michael Lim, Ie-Ming Shih, Tian-Li Wang and 9 more

Abstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Meredith L StoneDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Katherine B ChiappinelliDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Huili LiDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Lauren M MurphyDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Meghan E TraversDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Michael J TopperDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Dimitrios MathiosDepartment of Neurosurgery, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Michael LimDepartment of Neurosurgery, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Ie-Ming ShihDepartment of Gynecology and Obstetrics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Tian-Li WangDepartment of Pathology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Chien-Fu HungDepartment of Pathology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287.
Vipul BhargavaDiscovery Sciences, Janssen Research & Development, Spring House, PA 19477.
Karla R WiehagenImmuno-Oncology Discovery, Janssen Research & Development, Spring House, PA 19477.
Glenn S CowleyDiscovery Sciences, Janssen Research & Development, Spring House, PA 19477.
Kurtis E BachmanOncology Janssen Research & Development, Spring House, PA 19477.
Reiner StrickLaboratory for Molecular Medicine, Department of Gynaecology and Obstetrics, University-Clinic Erlangen, 91054 Erlangen, Germany.
Pamela L StrisselLaboratory for Molecular Medicine, Department of Gynaecology and Obstetrics, University-Clinic Erlangen, 91054 Erlangen, Germany.
Stephen B BaylinDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287; zahnoci@jhmi.edu sbaylin@jhmi.edu.
Cynthia A ZahnowDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287; zahnoci@jhmi.edu sbaylin@jhmi.edu.

Funding

Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
Epigenetic activation of the interferon response to sensitize cancers to immune therapyR00CA204592 · NCI · GEORGE WASHINGTON UNIVERSITY · PI CHIAPPINELLI, KATHERINE B · 2017 to 2019
$747k
NCI NIH HHS R00 CA204592NIGMS NIH HHS T32 GM008752
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationNeoplasmsDNAHumansDNA

Identifiers

PMID30181297
PMCPMC6140504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.