Evidence map›Paper›PMID 30181288›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Structural titration of receptor ion channel GLIC gating by HS-AFM.

Yi Ruan, Kevin Kao, Solène Lefebvre, Arin Marchesi, Pierre-Jean Corringer, Richard K Hite, Simon Scheuring

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. CNG channel structure, function, and gating: a tale of conformational flexibility.Pflugers Archiv : European journal of physiology · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. High-speed atomic force microscopy tracks the dynamic parts of the ribosome.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Physics of viral dynamics.Nature reviews. Physics · 2021
    Review
  19. Article
  20. Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Yi RuanCollaborative Innovation Center for Bio-Med Physics Information Technology, College of Science, Zhejiang University of Technology, 310023 Hangzhou, China.
Kevin KaoStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Solène LefebvreChannel-Receptors Unit, Institut Pasteur, CNRS UMR 3571, 75015 Paris, France.
Arin MarchesiU1006 INSERM, Université Aix-Marseille, Parc Scientifique et Technologique de Luminy, 13009 Marseille, France.
Pierre-Jean CorringerChannel-Receptors Unit, Institut Pasteur, CNRS UMR 3571, 75015 Paris, France.
Richard K HiteStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Simon ScheuringU1006 INSERM, Université Aix-Marseille, Parc Scientifique et Technologique de Luminy, 13009 Marseille, France; sis2019@med.cornell.edu.ORCID 0000-0003-3534-069X
Inserm · FRCentre National de la Recherche Scientifique · FRMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ProteinsCyanobacteriaCysteine Loop Ligand-Gated Ion Channel ReceptorsHydrogen-Ion ConcentrationIon Channel GatingMicroscopy, Atomic ForceProtein ConformationBacterial ProteinsCysteine Loop Ligand-Gated Ion Channel Receptorsconformational changeCys-loopGLICHS-AFMion channel

Identifiers

PMID30181288
PMCPMC6187180
OpenAlexW2891178648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.