Evidence map›Paper›PMID 30181262›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy.

Harry A T Pritchard, Paulo W Pires, Evan Yamasaki, Pratish Thakore, Scott Earley

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. G protein regulation by RGS proteins in the pathophysiology of dilated cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  5. Vascular Function and Ion Channels in Alzheimer's Disease.Microcirculation (New York, N.Y. : 1994) · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  11. Review
  12. Article
  13. CaThe Journal of physiology · 2022
    Article
  14. Article
  15. Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Harry A T PritchardCenter for Cardiovascular Research, Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318.
Paulo W PiresCenter for Cardiovascular Research, Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318.ORCID 0000-0001-5972-4554
Evan YamasakiCenter for Cardiovascular Research, Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318.
Pratish ThakoreCenter for Cardiovascular Research, Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318.
Scott EarleyCenter for Cardiovascular Research, Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318 searley@med.unr.edu.ORCID 0000-0001-9560-2941
University of Nevada, Reno · US

Funding

TRP Channel-Dependent Regulation of Arterial Tone (Renewal)R01HL091905 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2009 to 2020
$5.1M
Sensory mechanisms in brain capillary endothelial cells that initiate functional hyperemiaR01HL139585 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2018 to 2020
$1.7M
Structural Basis of Peripheral Coupling Sites Regulating Arterial Smooth Muscle Contractility (A1)R01HL137852 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT · 2018 to 2020
$1.6M
Cerebral functional hyperemia responses induced by capillary NMDA receptors are disrupted by amyloid-beta accumulationK99HL140106 · NHLBI · UNIVERSITY OF NEVADA RENO · PI PIRES, PAULO W · 2018 to 2019
$165k
NHLBI NIH HHS K99 HL140106NHLBI NIH HHS R01 HL091905NHLBI NIH HHS R01 HL137852NHLBI NIH HHS R01 HL139585
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) results from mutations in the gene encoding dystrophin which lead to impaired function of skeletal and cardiac muscle, but little is known about the effects of the disease on vascular smooth muscle cells (SMCs). Here we used the

Indexed as

AnimalsCalciumCalcium SignalingCells, CulturedCerebral ArteriesDystrophinHomeostasisLarge-Conductance Calcium-Activated Potassium ChannelsMaleMiceMice, Inbred mdxMuscle ContractionMuscle, Smooth, VascularMuscular Dystrophy, AnimalMuscular Dystrophy, DuchenneNanotechnologyCalciumDystrophinLarge-Conductance Calcium-Activated Potassium ChannelsRyanodine Receptor Calcium Release ChannelCa2+ signalingion channelssmooth musclesuperresolution microscopyvasoconstriction

Identifiers

PMID30181262
PMCPMC6187127
OpenAlexW2890307231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.