Evidence map›Paper›PMID 30181246›Full record

ArticlemBio2018

Removal of a Membrane Anchor Reveals the Opposing Regulatory Functions of Vibrio cholerae Glucose-Specific Enzyme IIA in Biofilms and the Mammalian Intestine.

Vidhya Vijayakumar, Audrey S Vanhove, Bradley S Pickering, Julie Liao, Braden T Tierney, John M Asara, Roderick Bronson, Paula I Watnick

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Structural insight intoActa biochimica et biophysica Sinica · 2025
    Article
  4. Sequestration of a dual function DNA-binding protein byProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Vidhya VijayakumarDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Audrey S VanhoveDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Bradley S PickeringDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Julie LiaoDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Braden T TierneyDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.
John M AsaraDivision of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Roderick BronsonDepartment of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Paula I WatnickDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA paula.watnick@childrens.harvard.edu.ORCID 0000-0002-9173-8662
Boston Children's Hospital · USHarvard University · USBeth Israel Deaconess Medical Center · US

Funding

Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
Global regulators converge to orchestrate metabolism, biofilm, and pathogenesisR01AI112652 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WATNICK, PAULA I · 2014 to 2025
$4.8M
NCI NIH HHS P01 CA120964NIAID NIH HHS R01 AI112652
6 · The paper itself

Abstract

The

Indexed as

Bacterial ProteinsBiofilmsGlucosePhosphoenolpyruvate Sugar Phosphotransferase SystemProtein BindingProtein DomainsSequence DeletionVibrio choleraeVirulence FactorsBacterial ProteinsGlucosephosphoenolpyruvate-glucose phosphotransferasePhosphoenolpyruvate Sugar Phosphotransferase SystemVirulence Factorsamphipathic helixbiofilmsphosphoenolpyruvate phosphotransferase systemsugar transportVibrio cholerae

Identifiers

PMID30181246
PMCPMC6123446
OpenAlexW2890727049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.