Evidence map›Paper›PMID 30181218›Full record

ArticleThe Journal of biological chemistry2018

Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts.

Sarah A Mereby, Tatsuya Maehigashi, Jessica M Holler, Dong-Hyun Kim, Raymond F Schinazi, Baek Kim

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

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  15. Article
  16. Positive selection in dNTPase SAMHD1 throughout mammalian evolution.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sarah A MerebyFrom the Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia 30322.ORCID 0000-0003-2600-9460
Tatsuya MaehigashiFrom the Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia 30322.
Jessica M HollerFrom the Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia 30322.
Dong-Hyun KimDepartment of Pharmacy, Kyung-Hee University, Seoul 130-701, South Korea, and.
Raymond F SchinaziFrom the Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia 30322.
Baek KimFrom the Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia 30322, baek.kim@emory.edu.
Emory University · USKyung Hee University · KR

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Lentivirus Replication Strategy and PathogenesisR01AI136581 · NIAID · EMORY UNIVERSITY · PI Baek Kim · 2018 to 2026
$3.9M
Towards Suppression and Elimination of HIV in the CNSR01MH116695 · NIMH · EMORY UNIVERSITY · PI SCHINAZI, RAYMOND FELIX, TYOR, WILLIAM R · 2018 to 2022
$3.4M
SAMHD1 controls dNTP pool and HIV sensitivity to NRTIsR01GM104198 · NIGMS · UNIVERSITY OF ROCHESTER · PI KIM, BAEK · 2012 to 2018
$2.3M
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI136581NIGMS NIH HHS R01 GM104198NIMH NIH HHS R01 MH116695
6 · The paper itself

Abstract

Lentiviruses infect both dividing CD4

Indexed as

Host-Pathogen InteractionsLentivirusAnimalsCatsHumansMicePrimatesProteasome Endopeptidase ComplexProteolysisReverse TranscriptionSAM Domain and HD Domain-Containing Protein 1Viral Regulatory and Accessory ProteinsProteasome Endopeptidase ComplexSAM Domain and HD Domain-Containing Protein 1Viral Regulatory and Accessory Proteinsantiviral defensedNTPaseimmunodeficiency viruslentivirusmacrophagenucleotideproteosomal degradationreverse transcriptionSAM domain and HD domain-containing protein 1 (SAMHD1)

Identifiers

PMID30181218
PMCPMC6200947
OpenAlexW2891604858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.