Evidence map›Paper›PMID 30181214›Full record

ArticleThe Journal of biological chemistry2018

Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8.

Chengfeng Merriman, Hua Li, Huilin Li, Dax Fu

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Genetic, Functional, and Immunological Study of ZnT8 in Diabetes.International journal of endocrinology · 2019
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chengfeng MerrimanFrom the Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and.
Hua Lithe Cryo-EM Structural Biology Laboratory, Van Andel Research Institute, Grand Rapids, Michigan 49503.ORCID 0000-0001-8085-8928
Huilin Lithe Cryo-EM Structural Biology Laboratory, Van Andel Research Institute, Grand Rapids, Michigan 49503.
Dax FuFrom the Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and dfu3@jhmi.edu.ORCID 0000-0002-2663-1316
Johns Hopkins University · USVan Andel Institute · US

Funding

Structure Biology of Mycobacterium Tuberculosis Pup-Proteasome PathwayR01AI070285 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI LI, HUILIN · 2007 to 2022
$6.5M
Structure and Mechanism of Zinc Efflux TransportersR01GM065137 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FU, DAX · 2002 to 2018
$5.6M
Molecular mechanism of intestinal zinc uptakeR01DK108599 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI FU, DAX · 2015 to 2018
$1.7M
Zeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584k
MoFlo to MoFlo XDP Upgrade for BSL3 SortingS10OD016315 · OD · JOHNS HOPKINS UNIVERSITY · PI MARGOLICK, JOSEPH B. · 2013 to 2013
$233k
NIAID NIH HHS R01 AI070285NIDDK NIH HHS R01 DK108599NIGMS NIH HHS R01 GM065137NIH HHS S10 OD016315NIH HHS S10 OD016374
6 · The paper itself

Abstract

Solute carrier family 30 member 8 (

Indexed as

Allosteric RegulationAntibodies, MonoclonalDiabetes Mellitus, Type 2Drug DiscoveryGenetic Predisposition to DiseaseHumansInsulin-Secreting CellsZinc Transporter 8Antibodies, MonoclonalSLC30A8 protein, humanZinc Transporter 8diabetesdrug discoverydrug screeningHTRFinhibitormAbmonoclonal antibodypancreatic beta-cellspancreatic islettherapeutic targettransportzincZnT8

Identifiers

PMID30181214
PMCPMC6200924
OpenAlexW2890065693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.