Evidence map›Paper›PMID 30181210›Full record

ArticleThe Journal of biological chemistry2018

Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens.

Roxanne P Smith, Biswaranjan Mohanty, Shakeel Mowlaboccus, Jason J Paxman, Martin L Williams, Stephen J Headey, Geqing Wang, Pramod Subedi, Bradley C Doak, Charlene M Kahler and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Roxanne P SmithFrom the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3086, Victoria, Australia.
Biswaranjan MohantyMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne 3052, Victoria, Australia, and.
Shakeel Mowlaboccusthe Marshall Center for Infectious Diseases Research and Training, School of Biomedical Sciences, University of Western Australia, Perth 6907, Western Australia, Australia.
Jason J PaxmanFrom the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3086, Victoria, Australia.
Martin L WilliamsMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne 3052, Victoria, Australia, and.
Stephen J HeadeyMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne 3052, Victoria, Australia, and.
Geqing WangFrom the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3086, Victoria, Australia.
Pramod SubediFrom the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3086, Victoria, Australia.
Bradley C DoakMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne 3052, Victoria, Australia, and.
Charlene M Kahlerthe Marshall Center for Infectious Diseases Research and Training, School of Biomedical Sciences, University of Western Australia, Perth 6907, Western Australia, Australia.
Martin J ScanlonMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne 3052, Victoria, Australia, and martin.scanlon@monash.edu.ORCID 0000-0002-9230-7506
Begoña HerasFrom the Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3086, Victoria, Australia, b.heras@latrobe.edu.au.ORCID 0000-0003-3469-7988
La Trobe University · AUMonash University · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The worldwide incidence of neisserial infections, particularly gonococcal infections, is increasingly associated with antibiotic-resistant strains. In particular, extensively drug-resistant

Indexed as

Protein ConformationAmino Acid SequenceBacterial ProteinsCatalytic DomainCrystallography, X-RayDisulfidesModels, MolecularNeisseria gonorrhoeaeOxidation-ReductionOxidoreductasesProtein DomainsBacterial ProteinsDisulfidesOxidoreductasescrystallographydisulfideDsbDelectron transferenzyme mechanismmicrobial pathogenesisNeisseria gonorrhoeaeprotein foldingprotein structure

Identifiers

PMID30181210
PMCPMC6204915
OpenAlexW2891365274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.