Evidence map›Paper›PMID 30181149›Full record

ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2018

Absolute 10-year risk of dementia by age, sex and

Katrine L Rasmussen, Anne Tybjærg-Hansen, Børge G Nordestgaard, Ruth Frikke-Schmidt

Abstract read
In one paragraph

Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. International journal of molecular sciences · 2025
    Pooled it
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  15. Validation of newly derived polygenic risk scores for dementia in a prospective study of older individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  16. Article
  17. Article
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  19. Frontiers in aging neuroscience · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katrine L RasmussenDepartment of Clinical Biochemistry (Rasmussen, Tybjærg-Hansen, Frikke-Schmidt), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry (Rasmussen, Nordestgaard), Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Anne Tybjærg-HansenDepartment of Clinical Biochemistry (Rasmussen, Tybjærg-Hansen, Frikke-Schmidt), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry (Rasmussen, Nordestgaard), Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Børge G NordestgaardDepartment of Clinical Biochemistry (Rasmussen, Tybjærg-Hansen, Frikke-Schmidt), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry (Rasmussen, Nordestgaard), Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry (Rasmussen, Tybjærg-Hansen, Frikke-Schmidt), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry (Rasmussen, Nordestgaard), Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark ruth.frikke-schmidt@regionh.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDementia is a major cause of disability, and risk-factor reduction may have the potential to delay or prevent the disease. Our aim was to determine the absolute 10-year risk of dementia, by age, sex and apolipoprotein E (

methodsWe obtained data from the Copenhagen General Population Study (from 2003 to 2014) and the Copenhagen City Heart Study (from 1991 to 1994 and 2001 to 2003). Participants underwent a questionnaire, physical examination and blood sampling at baseline. Diagnoses of dementia and cerebrovascular disease were obtained from the Danish National Patient Registry up to Nov. 10, 2014.

resultsAmong 104 537 individuals, the absolute 10-year risk of Alzheimer disease in 3017 women and men who were carriers of the

interpretationAge, sex and

Indexed as

AgingSex CharacteristicsAgedAged, 80 and overApolipoproteins EBiomarkersCohort StudiesDementiaDenmarkDisability EvaluationFemaleGene FrequencyGenotypeHumansMaleMiddle AgedApoE protein, humanApolipoproteins EBiomarkers

Identifiers

PMID30181149
PMCPMC6148649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.