ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Brief, But Not Prolonged, Pauses in the Firing of Midbrain Dopamine Neurons Are Sufficient to Produce a Conditioned Inhibitor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Methamphetamine potentiates the use of outcome-specific associations via a hypothalamic-dopamine circuit.Neuron · 2026Article
- KChIP4a is a Biophysical Amplifier of Inhibition in Atypical Dopamine Neurons and Controls Learning from Negative Prediction Errors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A brief history of dopamine prediction errors.Frontiers in computational neuroscience · 2026Review
- The curious case of dopaminergic prediction errors and learning associative information beyond value.Nature reviews. Neuroscience · 2025Review
- Optogenetic Inhibition of Rat Anterior Cingulate Cortex Impairs the Ability to Initiate and Stay on Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A dopamine mechanism for reward maximization.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Conditioned inhibition of fear and reward in male and female rats.Neurobiology of learning and memory · 2024Article
- Contexts facilitate dynamic value encoding in the mesolimbic dopamine system.bioRxiv : the preprint server for biology · 2023Article
- Dopamine signals as temporal difference errors: recent advances.Current opinion in neurobiology · 2021Review
- Neural substrates of appetitive and aversive prediction error.Neuroscience and biobehavioral reviews · 2021Review
- Past experience shapes the neural circuits recruited for future learning.Nature neuroscience · 2021Article
- Locus Coeruleus Activation Patterns Differentially Modulate Odor Discrimination Learning and Odor Valence in Rats.Cerebral cortex communications · 2021Article
- Dendritic Architecture PredictsFrontiers in neural circuits · 2021Article
- Article
- Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making.eLife · 2020Article
- Temporally restricted dopaminergic control of reward-conditioned movements.Nature neuroscience · 2020Article
- Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors.Nature neuroscience · 2020Article
- Article
- Article
- Recent advances in understanding the role of phasic dopamine activity.F1000Research · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Prediction errors are critical for associative learning. In the brain, these errors are thought to be signaled, in part, by midbrain dopamine neurons. However, although there is substantial direct evidence that brief increases in the firing of these neurons can mimic positive prediction errors, there is less evidence that brief pauses mimic negative errors. Whereas pauses in the firing of midbrain dopamine neurons can substitute for missing negative prediction errors to drive extinction, it has been suggested that this effect might be attributable to changes in salience rather than the operation of this signal as a negative prediction error. Here we address this concern by showing that the same pattern of inhibition will create a cue able to meet the classic definition of a conditioned inhibitor by showing suppression of responding in a summation test and slower learning in a retardation test. Importantly, these classic criteria were designed to rule out explanations founded on attention or salience; thus the results cannot be explained in this manner. We also show that this pattern of behavior is not produced by a single, prolonged, ramped period of inhibition, suggesting that it is precisely timed, sudden change and not duration that conveys the teaching signal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.