ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05763732 (Effects of Rhythmic Auditory Stimulation), which is not on this map. Cited by 91 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Rhythmic Auditory Stimulation (RAS) on Gait in Parkinson Disease (PD) Patients With DBS
Who cites it
91 citing papers in PubMed.
- Interactive mobile application for Parkinson's disease deep brain stimulation (MAP DBS): An open-label, multicenter, randomized, controlled clinical trial.Parkinsonism & related disorders · 2023Trial
- Neurofeedback-Linked Suppression of Cortical β Bursts Speeds Up Movement Initiation in Healthy Motor Control: A Double-Blind Sham-Controlled Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Trial
- Frequency-Specific EEG burst dynamics in Parkinson's Disease and freezing of gait.Journal of neurology · 2026Article
- Dopamine and the dynamics of subthalamic and leg muscle activities in parkinsonian stepping.Brain : a journal of neurology · 2026Article
- Cortico-pallidal beta dynamics underlie impaired turning in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Soft Neural Interfaces for Circuit-Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models.Advanced healthcare materials · 2026Article
- Spatial propagation of movement-related basal ganglia activity predicts parkinsonian motor state.Brain : a journal of neurology · 2026Article
- Characterising motor and cognitive contributions of cortical beta oscillations and their modulation with rTMS.NeuroImage · 2026Article
- Article
- Stroke recovery beyond initial severity: the complementary roles of brain structure and brain function in acute stroke.Brain communications · 2026Article
- Reduced pre-movement subthalamic beta desynchronization marks motor deficit in Parkinson's disease.Brain communications · 2026Article
- An Improved Beta Burst Extraction for Chip-Based Deep Brain Stimulation With Real-Time Model Updating.IEEE open journal of engineering in medicine and biology · 2026Article
- A meta-analysis of periodic and aperiodic electrophysiological features in Parkinson's disease.Brain communications · 2026Review
- Prediction of Pathological Subthalamic Nucleus Beta Burst Occurrence in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Low β predicts motor output and cell degeneration in the A53T Parkinson's disease rat model.Brain : a journal of neurology · 2025Article
- Subthalamic stimulation evokes hyperdirect high beta interruption and cortical high gamma entrainment in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Common and Unique Neurophysiological Processes That Support the Stopping and Revising of Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson's disease.Brain : a journal of neurology · 2025Article
- Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson's disease.Frontiers in neuroscience · 2025Article
- An active inference account of stuttering behavior.Frontiers in human neuroscience · 2025Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Considerable evidence suggests a role of beta-band oscillations in voluntary movements. However, most of the studies linking beta power to motor performance are based on data averaged across trials that ignore the fast dynamics of oscillatory activity and trial-to-trial variations in motor responses. Recently, emphasis has shifted from the functional implications of the mean beta power to the presence and nature of episodic bursts of beta activity. Here we test the hypothesis that beta bursts, though short in duration in more physiological state, may help explain spontaneous variations in motor behavior of human adults at the single-trial level. To this end, we recorded local field potential activity from the subthalamic nucleus of parkinsonian patients of both genders whose motor behavior had been normalized as far as possible through treatment with the dopamine prodrug, levodopa. We found that beta bursts present in a time-limited window well before movement onset in the contralateral subthalamic nucleus reduce the peak velocity of that movement and that this effect is further amplified by the amplitude of the burst. Additionally, prolonged reaction times are observed when bursts occur immediately after the GO cue. Together, these results suggest that the modulation of the timing and amplitude of beta bursts might serve to dynamically adapt motor performance. These results offer new insight in the pathology of Parkinson's disease, and suggest that beta bursts whose presence and nature are modulated by context may have a physiological role in modulating behavior.
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Registered trials
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