Evidence map›Paper›PMID 30180947›Full record

ArticleBiochemical and biophysical research communications2018

Molecular mechanism for the inhibition of DXO by adenosine 3',5'-bisphosphate.

Ji-Sook Yun, Je-Hyun Yoon, Young Jun Choi, Young Jin Son, Sunghwan Kim, Liang Tong, Jeong Ho Chang

Open access · greenAbstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. RNA (New York, N.Y.) · 2025
    Article
  4. Article
  5. Article
  6. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ji-Sook YunDepartment of Biology Education, Kyungpook National University, Daegu 41566, South Korea.
Je-Hyun YoonDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Young Jun ChoiDepartment of Biology Education, Kyungpook National University, Daegu 41566, South Korea.
Young Jin SonNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, South Korea.
Sunghwan KimNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, South Korea.
Liang TongDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA. Electronic address: ltong@columbia.edu.
Jeong Ho ChangDepartment of Biology Education, Kyungpook National University, Daegu 41566, South Korea; Department of Biological Sciences, Columbia University, New York, NY 10027, USA. Electronic address: jhcbio@knu.ac.kr.
Columbia University · USDaegu-Gyeongbuk Medical Innovation Foundation · KRKyungpook National University · KRMedical University of South Carolina · US

Funding

Structural and functional studies of mRNA processing, stability and quality controlR35GM118093 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LIANG TONG · 2016 to 2026
$8.5M
Case Center for Synchrotron BiosciencesP30EB009998 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI CHANCE, MARK R · 2009 to 2018
$8.4M
NIBIB NIH HHS P30 EB009998NIGMS NIH HHS R35 GM118093
6 · The paper itself

Abstract

The decapping exoribonuclease DXO functions in pre-mRNA capping quality control, and shows multiple biochemical activities such as decapping, deNADding, pyrophosphohydrolase, and 5'-3' exoribonuclease activities. Previous studies revealed the molecular mechanisms of DXO based on the structures in complexes with a product, substrate mimic, cap analogue, and 3'-NADP

Indexed as

Adenosine DiphosphateBinding SitesEndoribonucleasesExoribonucleasesMagnesiumModels, Molecularadenosine 3'-phosphate-5'-phosphateAdenosine DiphosphateEndoribonucleasesExoribonucleasesMagnesiummRNA decapping enzymes5′-3′ exoribonucleaseAdenosine 3′,5′-bisphosphateCrystalDXONuclease inhibitor

Identifiers

PMID30180947
PMCPMC6145842
OpenAlexW2889105342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.