Evidence map›Paper›PMID 30180815›Full record

ArticleBMC nephrology2018

Anxiety, depression, and regret of donation in living kidney donors.

Courtenay M Holscher, Joseph Leanza, Alvin G Thomas, Madeleine M Waldram, Christine E Haugen, Kyle R Jackson, Sunjae Bae, Allan B Massie, Dorry L Segev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Psychological Impact of Living Kidney Donation: A Systematic Review by the EAU-YAU Kidney Transplant Working Group.Transplant international : official journal of the European Society for Organ Transplantation · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Courtenay M HolscherDepartment of Surgery, Johns Hopkins University School of Medicine, 2000 E. Monument St., Baltimore, MD, 21205, USA. cholsch1@jhmi.edu.ORCID 0000-0002-5808-5954
Joseph LeanzaDepartment of Surgery, Johns Hopkins University School of Medicine, 2000 E. Monument St., Baltimore, MD, 21205, USA.
Alvin G ThomasDepartment of Surgery, Johns Hopkins University School of Medicine, 2000 E. Monument St., Baltimore, MD, 21205, USA.
Madeleine M WaldramDepartment of Surgery, Johns Hopkins University School of Medicine, 2000 E. Monument St., Baltimore, MD, 21205, USA.
Christine E HaugenDepartment of Surgery, Johns Hopkins University School of Medicine, 2000 E. Monument St., Baltimore, MD, 21205, USA.
Kyle R JacksonDepartment of Surgery, Johns Hopkins University School of Medicine, 2000 E. Monument St., Baltimore, MD, 21205, USA.
Sunjae BaeDepartment of Surgery, Johns Hopkins University School of Medicine, 2000 E. Monument St., Baltimore, MD, 21205, USA.
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, 2000 E. Monument St., Baltimore, MD, 21205, USA.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, 2000 E. Monument St., Baltimore, MD, 21205, USA.
Johns Hopkins University · US

Funding

Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Differential Survival Benefit of Incompatible Living Donor Kidney Transplantation: Modeling Outcomes for Different Patient PhenotypesF32DK113719 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JACKSON, KYLE R · 2017 to 2019
$238k
Trajectory of post-donation renal function in living kidney donorsF32DK109662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HOLSCHER, COURTENAY · 2016 to 2018
$232k
Novel Frailty Phenotype in Older Adults with End-Stage Renal DiseaseF32AG053025 · NIA · JOHNS HOPKINS UNIVERSITY · PI HAUGEN, CHRISTINE · 2016 to 2019
$204k
NIA NIH HHS F32 AG053025NIDDK NIH HHS F32 DK109662NIDDK NIH HHS F32 DK113719NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK096008
6 · The paper itself

Abstract

backgroundPrevious studies have reported a wide range of prevalence of post-donation anxiety, depression, and regret in living kidney donors (LKDs). It is also unclear what risk factors are associated with these outcomes.

methodsWe screened 825 LKDs for anxiety and depression using 2-item GAD-2 and PHQ-2 scales and asked about regret.

resultsOverall, 5.5% screened positive for anxiety, 4.2% for depression, and 2.1% reported regretting their donation. While there was moderate correlation between positive anxiety and depression screens (r = 0.52), there was no correlation between regret and positive screens (r < 0.1 for both). A positive anxiety screen was more likely in LKDs with a positive depression screen (adjusted relative risk [aRR] 13.72, 95% confidence interval [CI] 6.78-27.74, p < 0.001). Similarly, a positive depression screen was more likely in LKDs with a positive anxiety screen (aRR 19.50, 95% CI 6.94-54.81, p < 0.001), as well as in those whose recipients experienced graft loss (aRR 5.38, 95% CI 1.29-22.32, p = 0.02). Regret was more likely in LKDs with a positive anxiety screen (aRR 5.68, 95% CI 1.20-26.90, p = 0.03). This was a single center cross-sectional study which may limit generalizability and examination of causal effects. Also, due to the low prevalence of adverse psychosocial outcomes, we may lack power to detect some associations between donor characteristics and anxiety, depression, or regret.

conclusionsAlthough there is a low prevalence of anxiety, depression, and regret of donation among LKDs, these are interrelated conditions and a positive screen for one condition should prompt evaluation for other conditions.

Indexed as

EmotionsAdultAnxietyCohort StudiesCross-Sectional StudiesDepressionFemaleFollow-Up StudiesHealth SurveysHumansKidney TransplantationLiving DonorsMaleMiddle AgedNephrectomyQuality of LifeAnxietyDepressionDonor follow-upGAD-2Kidney transplantationLiving donorsMental health screeningPHQ-2Psychiatric screeningQuality of life

Identifiers

PMID30180815
PMCPMC6122576
OpenAlexW2892181195

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.