ArticlePloS one2018
Executive function in end-stage renal disease: Acute effects of hemodialysis and associations with clinical factors.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07377500 (Randomised Controlled Trial of Dialysate Cooling for the Preservation of Cognitive Function in People Receiving Haemodialysis), which is not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomised Controlled Trial of Dialysate Cooling for the Preservation of Cognitive Function in People Receiving Haemodialysis
Who cites it
11 citing papers in PubMed.
- Assessing Functional Cognition in People on Maintenance Hemodialysis Using Performance-Based Testing.Kidney360 · 2026Article
- Mind Over Matter: Cognitive Decline in Hemodialysis Patients: A Cross-sectional Analysis.Annals of African medicine · 2026Observational
- Altered brain entropy and functional connectivity patterns in peritoneal dialysis patients.Frontiers in neuroscience · 2026Article
- Narrative Review: Clinical Implications and Assessment of Frailty in Patients With Advanced CKD.Kidney international reports · 2024Review
- A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodialysis in Southern Spain.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Delirium, changes in cognitive function, and risk of diagnosed dementia after kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Cognitive Dysfunction and Its Risk Factors in Patients Undergoing Maintenance Hemodialysis.Neuropsychiatric disease and treatment · 2022Article
- Cognitive impairment burden in older and younger adults across the kidney transplant care continuum.Clinical transplantation · 2021Article
- Interventions to Preserve Cognitive Functioning Among Older Kidney Transplant Recipients.Current transplantation reports · 2020Article
- The relationship between cognitive function and having diabetes in patients treated with hemodialysis.International journal of nursing sciences · 2020Article
- Exercise and cognitive function in patients with end-stage kidney disease.Seminars in dialysis · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere is evidence of cognitive impairment in patients with end-stage renal disease in hemodialysis (ESRD-HD). However, few studies have exhaustively analyzed executive functions (EFs) in this population, especially considering the influence of a wide range of clinical variables. This study analyzes performance in different EF components in ESRD-HD patients compared to a group of healthy controls (HCs), in addition to the acute effects of HD and the associations of cognitive performance with clinical variables.
methodEFs were evaluated pre- and post-HD in 43 ESRD-HD patients and 42 HCs, using a battery of tests designed to assess EF domains. Age, schooling, mood and blood pressure were statistically controlled. Associations between performance and clinical factors were computed by correlations and hierarchical multiple regression analyses.
resultsThe performance of the ESRD-HD patients was significantly lower than that of HCs in all the EF domains except for planning. Group differences were marginally significant for reasoning. HD produced no acute changes in global performance, with improvements see only in inhibition and working memory. EF scores were positively associated with total number of months previously transplanted, body mass index (BMI), dry weight, and levels of hemoglobin, albumin, ferritin, calcium, phosphorus, sodium, urea, and creatinine.
conclusionsGlobal EF functioning was lower in ESRD-HD patients than in HCs. No major acute HD-related EF changes were detected. These findings underline the importance of an adequate nutritional status for maintaining executive functioning in ESRD-HD patients.
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