ArticlePLoS genetics2018
Epistatic control of intrinsic resistance by virulence genes in Listeria.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Predicting Antibiotic Resistance inInternational journal of molecular sciences · 2025Pooled it
- Genetic diversity of Listeria monocytogenes isolates in Colombia from 2010 until 2017 and comparison against the PulseNet regional surveillance networkBiomedica : revista del Instituto Nacional de Salud · 2026Article
- Molecular Characterization ofInternational journal of women's health · 2026Article
- Clindamycin susceptibility and virulence characterization ofFrontiers in microbiology · 2026Article
- Hybrid Genome Sequencing and Comparative Analysis of Three NovelFoods (Basel, Switzerland) · 2025Article
- Genetic exchange networks bridge mobile DNA vehicles in the bacterial pathogen Listeria monocytogenes.Nature communications · 2025Article
- Genomic analysis of Listeria monocytogenes diversity over a 10-year period in Uruguay.Scientific reports · 2025Article
- Listeriosis.Nature reviews. Disease primers · 2025Review
- Genomic characterization ofMicrobial genomics · 2025Article
- Evidence of horizontal gene transfer and environmental selection impacting antibiotic resistance evolution in soil-dwelling Listeria.Nature communications · 2024Article
- Preserving the efficacy of antibiotics to tackle antibiotic resistance.Microbial biotechnology · 2024Review
- Phenotypic and genotypic antimicrobial resistance ofThe Lancet regional health. Europe · 2024Article
- Impact of veterinary pharmaceuticals on environment and their mitigation through microbial bioremediation.Frontiers in microbiology · 2024Review
- Genomic Characterization ofPathogens (Basel, Switzerland) · 2023Article
- Protein Interaction Network Analysis to Investigate Stress Response, Virulence, and Antibiotic Resistance Mechanisms inMicroorganisms · 2023Article
- Human Listeriosis.Clinical microbiology reviews · 2023Review
- Genetic Characterization ofFoods (Basel, Switzerland) · 2023Article
- Cyclic di-AMP, a multifaceted regulator of central metabolism and osmolyte homeostasis inmicroLife · 2023Review
- Whole-genome sequencing ofFrontiers in microbiology · 2023Article
- Comparative Genomics of Listeria monocytogenes Isolates from Ruminant Listeriosis Cases in the Midwest United States.Microbiology spectrum · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Elucidating the relationships between antimicrobial resistance and virulence is key to understanding the evolution and population dynamics of resistant pathogens. Here, we show that the susceptibility of the gram-positive bacterium Listeria monocytogenes to the antibiotic fosfomycin is a complex trait involving interactions between resistance and virulence genes and the environment. We found that a FosX enzyme encoded in the listerial core genome confers intrinsic fosfomycin resistance to both pathogenic and non-pathogenic Listeria spp. However, in the genomic context of the pathogenic L. monocytogenes, FosX-mediated resistance is epistatically suppressed by two members of the PrfA virulence regulon, hpt and prfA, which upon activation by host signals induce increased fosfomycin influx into the bacterial cell. Consequently, in infection conditions, most L. monocytogenes isolates become susceptible to fosfomycin despite possessing a gene that confers high-level resistance to the drug. Our study establishes the molecular basis of an epistatic interaction between virulence and resistance genes controlling bacterial susceptibility to an antibiotic. The reported findings provide the rationale for the introduction of fosfomycin in the treatment of Listeria infections even though these bacteria are intrinsically resistant to the antibiotic in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.