Evidence map›Paper›PMID 30180125›Full record

ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2018

Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

Stacey L Valentine, Melania M Bembea, Jennifer A Muszynski, Jill M Cholette, Allan Doctor, Phillip C Spinella, Marie E Steiner, Marisa Tucci, Nabil E Hassan, Robert I Parker and 34 more

Open access · greenAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 6 pooled it
7.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 6 syntheses or guidelines pooled it, 201 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Prophylactic red blood cell transfusions in children and neonates with cancer: An evidence-based clinical practice guideline.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Guideline
  4. Guideline
  5. Guideline
  6. Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018
    Guideline
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Patient Blood Management in Pediatric Patients: Current Strategies and Future PerspectivesTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025
    Review
  19. Massive Bleeding in Children With Cancer or Hematopoietic Cell Transplant: International, Multicenter Retrospective Study, 2017-2021.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
    Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 20 institutions in 5 countries.

Stacey L ValentineDivision of Pediatric Critical Care, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA.
Melania M BembeaDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Jennifer A MuszynskiDivision of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH.
Jill M CholetteDepartment of Pediatrics, University of Rochester, Rochester, NY.
Allan DoctorDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Phillip C SpinellaDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Marie E SteinerDepartment of Pediatrics, University of Minnesota, Minneapolis, MN.
Marisa TucciDepartment of Pediatrics, University of Montreal, Montreal, QC, Canada.
Nabil E HassanDepartment of Pediatrics, University of Illinois College of Medicine, Peoria, IL.
Robert I ParkerDepartment of Pediatrics, Stony Brook University, Stony Brook, NY.
Jacques LacroixDepartment of Pediatrics, University of Montreal, Montreal, QC, Canada.
Andrew ArgentDepartment of Pediatrics, University of Cape Town, Cape Town, South Africa.
Jeffrey L CarsonDepartment of Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
Kenneth E RemyDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Pierre DemaretDepartment of Pediatrics, CHC, Liege, Belgium.
Guillaume EmeriaudDepartment of Pediatrics, University of Montreal, Montreal, QC, Canada.
Martin C J KneyberDepartment of Pediatrics, University of Groningen, Groningen, The Netherlands.
Nina GuzzettaDepartment of Anesthesiology, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA.
Mark W HallDivision of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH.
Duncan MacraePediatric Critical Care, Royal Brompton Hospital, London, United Kingdom.
Oliver KaramDepartment of Pediatrics, Professor and Director Pediatric Nephrology, Childrens Hospital of Richmond, Virginia Commonwealth University, Richmond, VA.
Robert T RussellDepartment of Surgery, University of Alabama Birmingham, Birmingham, AL.
Paul A StrickerDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA.
Adam M VogelDivision of Pediatric Surgery and Pediatrics, Baylor College of Medicine, Houston, TX.
Robert C TaskerDepartments of Neurology and Anesthesia (Pediatrics), Harvard Medical School, Boston, MA.
Alexis F TurgeonDepartment of Anesthesiology and Critical Care Medicine, Univesite Laval Research Center, Quebec City, QC, Canada.
Steven M SchwartzDepartment of Critical Care Medicine and Paediatrics, University of Toronto, ON, Canada.
Ariane WillemsPediatric Intensive Care Unit, University of Brussels, Brussels, Belgium.
Cassandra D JosephsonDepartment of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA.
Naomi L C LubanDepartment of Pediatrics and Pathology, George Washington University, Washington, DC.
Leslie E LehmannDepartment of Pediatrics, Harvard Medical School, Boston, MA.
Simon J StanworthDepartment of Medicine, University of Oxford, Oxford, United Kingdom.
Nicole D ZantekDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Timothy E BunchmanDepartment of Pediatrics, Professor and Director Pediatric Nephrology, Childrens Hospital of Richmond, Virginia Commonwealth University, Richmond, VA.
Ira M CheifetzDepartment of Pediatrics, Duke University, Durham, NC.
James D FortenberryDepartment of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA.
Meghan DelaneyDivision of Pathology and Laboratory Medicine, Children's National Health System, Washington, DC.
Leo van de WateringSanquin-Leiden University Medical Center, Leiden, The Netherlands.
Karen A RobinsonDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Sara MaloneDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Katherine M SteffenDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, CA.
Scot T BatemanDivision of Pediatric Critical Care, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA.
Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)
Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Washington University in St. Louis · USUniversité de Montréal · CAChildren's Healthcare of Atlanta · USJohns Hopkins Medicine · USNationwide Children's Hospital · USUniversity of Massachusetts Chan Medical School · USUniversity of Minnesota · USDuke University · USEmory University · USHarvard University · USIllinois College · USRoyal Brompton Hospital · GBRutgers, The State University of New Jersey · USStanford University · USStony Brook University · USUniversity of Alabama at Birmingham · USUniversity of Cape Town · ZAUniversity of Groningen · NLUniversity of Oxford · GBUniversity of Pennsylvania · US

Funding

Impact of Red Blood Cell (RBC)-Derived DAMPs on Host Immune Response in Pediatric SepsisK08GM129763 · NIGMS · WASHINGTON UNIVERSITY · PI REMY, KENNETH EUGENE · 2018 to 2021
$714k
Novel methods for brain injury detection and outcome prediction in pediatric ECMOK23NS076674 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BEMBEA, MELANIA MARIA · 2013 to 2015
$569k
Pediatric Critical Care Transfusion and Anemia Expertise InitiativeR13HD088086 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BATEMAN, SCOT THOMAS · 2016 to 2016
$9k
NICHD NIH HHS R13 HD088086NIGMS NIH HHS K08 GM129763NINDS NIH HHS K23 NS076674
6 · The paper itself

Abstract

objectivesTo date, there are no published guidelines to direct RBC transfusion decision-making specifically for critically ill children. We present the recommendations from the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.

designConsensus conference series of multidisciplinary, international experts in RBC transfusion management of critically ill children.

settingNot applicable.

interventionNone. SUBJECTS: Children with, or children at risk for, critical illness who receive or are at risk for receiving a RBC transfusion.

methodsA panel of 38 content and four methodology experts met over the course of 2 years to develop evidence-based, and when evidence lacking, expert consensus-based recommendations regarding decision-making for RBC transfusion management and research priorities for transfusion in critically ill children. The experts focused on nine specific populations of critically ill children: general, respiratory failure, nonhemorrhagic shock, nonlife-threatening bleeding or hemorrhagic shock, acute brain injury, acquired/congenital heart disease, sickle cell/oncology/transplant, extracorporeal membrane oxygenation/ventricular assist/ renal replacement support, and alternative processing. Data to formulate evidence-based and expert consensus recommendations were selected based on searches of PubMed, EMBASE, and Cochrane Library from 1980 to May 2017. Agreement was obtained using the Research and Development/UCLA Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. MEASUREMENTS AND

resultsThe Transfusion and Anemia Expertise Initiative consensus conference developed and reached consensus on a total of 102 recommendations (57 clinical [20 evidence based, 37 expert consensus], 45 research recommendations). All final recommendations met agreement, defined a priori as greater than 80%. A decision tree to aid clinicians was created based on the clinical recommendations.

conclusionsThe Transfusion and Anemia Expertise Initiative recommendations provide important clinical guidance and applicable tools to avoid unnecessary RBC transfusions. Research recommendations identify areas of focus for future investigation to improve outcomes and safety for RBC transfusion.

Indexed as

AdolescentChildChild, PreschoolConsensusCritical IllnessErythrocyte TransfusionHumansInfantInfant, Newborn

Identifiers

PMID30180125
PMCPMC6126913
OpenAlexW2890810853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.