Evidence map›Paper›PMID 30180019›Full record

ArticleJournal of glaucoma2018

The Fovea-BMO Axis Angle and Macular Thickness Vertical Asymmetry Across The Temporal Raphe.

Zeinab Ghassabi, Andrew H Nguyen, Navid Amini, Sharon Henry, Joseph Caprioli, Kouros Nouri-Mahdavi

Open access · greenAbstract read
In one paragraph

Article in Journal of glaucoma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zeinab GhassabiGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles.
Andrew H NguyenGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles.
Navid AminiDepartment of Computer Science, California State University Los Angeles, Los Angeles, CA.
Sharon HenryGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles.
Joseph CaprioliGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles.
Kouros Nouri-MahdaviGlaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles.
University of California, Los Angeles · USCalifornia State University Los Angeles · US

Funding

Detection of Glaucoma Progression with Macular OCT ImagingK23EY022659 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NOURI-MAHDAVI, KOUROS · 2012 to 2016
$1.1M
NEI NIH HHS K23 EY022659
6 · The paper itself

Abstract

purposeTo test the hypothesis that the fovea-Bruch's membrane opening (FoBMO) axis angle influences the thickness symmetry of the macular ganglion cell/inner plexiform layer (GCIPL) across the temporal horizontal meridian in normal subjects.

designCross-sectional diagnostic study at a tertiary academic center.

methodsOne hundred sixteen eyes of 60 normal subjects aged 40 to 85 years underwent spectral domain optical coherence tomography(SD-OCT) imaging. The FoBMO angle was estimated on en face infrared SD-OCT images. Posterior Pole algorithm images acquired with Spectralis SD-OCT were used to define vertical asymmetry as follows. The average thickness difference between the 3 most temporal superpixels above and below the horizontal meridian, the second row of superpixels from the horizontal meridian, and 3 central superpixels above and below the horizontal meridian were calculated. Factors influencing GCIPL thickness asymmetry were explored and changes in thickness asymmetry as a function of FoBMO angle were investigated.

resultsNo demographic or clinical factors affected temporal GCIPL asymmetry (P>0.05 for all). A more (negatively) tilted FoBMO angle was associated with relatively thinner inferior compared with superior GCIPL thickness in superpixels immediately adjacent to the temporal raphe (P<0.001). The second row of temporal superpixels from the horizontal meridian (P=0.349) or central superpixels (P=0.292) did not show this tendency.

conclusionsVertical GCIPL symmetry across the horizontal meridian is influenced by the FoBMO angle. SD-OCT algorithms using vertical asymmetry as a diagnostic index should be adjusted for the FoBMO angle.

Indexed as

AdultAgedAged, 80 and overAlgorithmsBruch MembraneCross-Sectional StudiesFemaleFovea CentralisHumansIntraocular PressureMacula LuteaMaleMiddle AgedOptic DiskRetinal Ganglion CellsTomography, Optical Coherence

Identifiers

PMID30180019
PMCPMC6218280
OpenAlexW2889114143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.