Evidence map›Paper›PMID 30179766›Full record

ReviewEnvironment international2018

The Seveso accident: A look at 40 years of health research and beyond.

Brenda Eskenazi, Marcella Warner, Paolo Brambilla, Stefano Signorini, Jennifer Ames, Paolo Mocarelli

Abstract readReview
In one paragraph

Review in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The Reverse Risk Register Approach to Understanding Systemic Factors in Risk Analysis and Management Case Studies.Risk analysis : an official publication of the Society for Risk Analysis · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Aryl hydrocarbon receptor activation alters emergency hematopoiesis during influenza A virus infection.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Dioxins vs. PFAS: Science and Policy Challenges.Environmental health perspectives · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brenda EskenaziCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA. Electronic address: eskenazi@berkeley.edu.
Marcella WarnerCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA.
Paolo BrambillaDepartment of Laboratory Medicine, University of Milano-Bicocca, School of Medicine, Hospital of Desio, Desio-Milano, Italy.
Stefano SignoriniDepartment of Laboratory Medicine, University of Milano-Bicocca, School of Medicine, Hospital of Desio, Desio-Milano, Italy.
Jennifer AmesCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA.
Paolo MocarelliDepartment of Laboratory Medicine, University of Milano-Bicocca, School of Medicine, Hospital of Desio, Desio-Milano, Italy.

Funding

In Utero Dioxin Exposure in Seveso, Italy and Health of the Second GenerationR01ES007171 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1996 to 2017
$7.1M
ENDOMETRIOSIS AND DIOXIN EXPOSURE OF RESIDENTS OF SEVESOF06TW002075 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1994 to 1994
–
FIC NIH HHS F06 TW002075NIEHS NIH HHS R01 ES007171
6 · The paper itself

Abstract

A 1976 chemical factory explosion near Seveso, Italy exposed residents to high levels of 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD or dioxin). Dioxin is a known human carcinogen and potent endocrine disruptor. It is highly lipophilic and has a long half-life in humans. Much of what we know and can learn about the risks of dioxin exposure on human health arose from the tragic circumstances of Seveso. This review aims to describe the Seveso accident, summarize the results of 40 years of research on the health of the Seveso population since the accident, and discuss next-stage research on the health of Seveso residents, their children, and grandchildren.

Indexed as

DioxinsEnvironmental ExposureSeveso Accidental ReleaseAnimalsFemaleHumansItalyMaternal-Fetal ExchangePregnancyResearchDioxinsDioxinDisasterEpidemiologySevesoTCDD

Identifiers

PMID30179766
PMCPMC6221983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.