Evidence map›Paper›PMID 30179753›Full record

ArticleJournal of chromatography. B, Analytical technologies in the biomedical and life sciences2018

The volatile molecular profiles of seven Streptococcus pneumoniae serotypes.

Theodore R Mellors, Christiaan A Rees, Flavio A Franchina, Alison Burklund, Chaya Patel, Lucy J Hathaway, Jane E Hill

Abstract read
In one paragraph

Article in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Theodore R MellorsThayer School of Engineering at Dartmouth, 14 Engineering Drive, Hanover, NH 03755, United States. Electronic address: theodore.r.mellors.th@dartmouth.edu.
Christiaan A ReesGeisel School of Medicine at Dartmouth, 1 Rope Ferry Road, Hanover, NH 03755, United States.
Flavio A FranchinaThayer School of Engineering at Dartmouth, 14 Engineering Drive, Hanover, NH 03755, United States.
Alison BurklundThayer School of Engineering at Dartmouth, 14 Engineering Drive, Hanover, NH 03755, United States.
Chaya PatelGeisel School of Medicine at Dartmouth, 1 Rope Ferry Road, Hanover, NH 03755, United States.
Lucy J HathawayInstitute for Infectious Diseases, Faculty of Medicine, University of Bern, Bern, Switzerland.
Jane E HillThayer School of Engineering at Dartmouth, 14 Engineering Drive, Hanover, NH 03755, United States; Geisel School of Medicine at Dartmouth, 1 Rope Ferry Road, Hanover, NH 03755, United States.

Funding

Quantitative Biomedical Sciences at DartmouthT32LM012204 · NLM · DARTMOUTH COLLEGE · PI TOSTESON, TOR D · 2016 to 2020
$876k
NLM NIH HHS T32 LM012204
6 · The paper itself

Abstract

In this study, the volatile molecule profile of Streptococcus pneumoniae serotypes was evaluated using solid phase microextraction (SPME) and two dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS). Here, seven serotypes (6B, 14, 15, 18C, 19F, 9V, and 23F) were analyzed in an isogenic background. We identified 13 core molecules associated with all seven serotypes, and seven molecules that were differentially produced between serotypes. Serotype 14 was found to have the most distinct volatile profile, and could be discriminated from the other six serotypes in aggregate with an area under the curve (AUC) of 89%. This study suggests that molecules from S. pneumoniae culture headspace show potential for rapid serotype identification.

Indexed as

Area Under CurveBacterial Typing TechniquesHumansPneumococcal InfectionsSerotypingStreptococcus pneumoniaeVolatile Organic CompoundsVolatile Organic Compounds

Identifiers

PMID30179753
PMCPMC6511392

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.