ArticleNeuroImage2018
Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review.Schizophrenia bulletin · 2024Pooled it
- Longitudinal Structural MRI Findings in Individuals at Genetic and Clinical High Risk for Psychosis: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Polygenic risk for schizophrenia is associated with white matter microstructure, cognitive and mental health.Schizophrenia (Heidelberg, Germany) · 2025Article
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
- Large language models can extract metadata for annotation of human neuroimaging publications.Frontiers in neuroinformatics · 2025Article
- Efficiency of structural brain networks mediates age-associated differences in executive functioning in older adults.Frontiers in aging neuroscience · 2025Article
- Characterization of cortical volume and whole-brain functional connectivity in Parkinson's disease patients: a MRI study combined with physiological aging brain changes.Frontiers in neuroscience · 2024Article
- Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study.Molecular psychiatry · 2022Article
- Brain and cognitive ageing: The present, and some predictions (…about the future).Aging brain · 2022Article
- A Possible White Matter Compensating Mechanism in the Brain of Relatives of People Affected by Psychosis Inferred from Repeated Long-Term DTI Scans.Schizophrenia bulletin open · 2022Article
- Identification of voxel-based texture abnormalities as new biomarkers for schizophrenia and major depressive patients using layer-wise relevance propagation on deep learning decisions.Psychiatry research. Neuroimaging · 2021Article
- Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank.Translational psychiatry · 2021Article
- Associations between hemispheric asymmetry and schizophrenia-related risk genes in people with schizophrenia and people at a genetic high risk of schizophrenia.The British journal of psychiatry : the journal of mental science · 2021Article
- Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI.Experimental neurobiology · 2021Article
- Grey and white matter associations of psychotic-like experiences in a general population sample (UK Biobank).Translational psychiatry · 2021Article
- Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease.Frontiers in human neuroscience · 2021Article
- Genetic Influence Underlying Brain Connectivity Phenotype: A Study on Two Age-Specific Cohorts.Frontiers in genetics · 2021Article
- White Matter Microstructure across the Psychosis Spectrum.Trends in neurosciences · 2020Review
- The effect of network thresholding and weighting on structural brain networks in the UK Biobank.NeuroImage · 2020Article
- Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank.Translational psychiatry · 2020Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Higher polygenic risk score for schizophrenia (szPGRS) has been associated with lower cognitive function and might be a predictor of decline in brain structure in apparently healthy populations. Age-related declines in structural brain connectivity-measured using white matter diffusion MRI -are evident from cross-sectional data. Yet, it remains unclear how graph theoretical metrics of the structural connectome change over time, and whether szPGRS is associated with differences in ageing-related changes in human brain connectivity. Here, we studied a large, relatively healthy, same-year-of-birth, older age cohort over a period of 3 years (age ∼ 73 years, N = 731; age ∼76 years, N = 488). From their brain scans we derived tract-averaged fractional anisotropy (FA) and mean diffusivity (MD), and network topology properties. We investigated the cross-sectional and longitudinal associations between these structural brain variables and szPGRS. Higher szPGRS showed significant associations with longitudinal increases in MD in the splenium (β = 0.132, p
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.