ArticleAnalytical chemistry2018
Glycan Isomer Identification Using Ultraviolet Photodissociation Initiated Radical Chemistry.
Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Analytical Strategies for Natural Mono- and Disaccharide Isomer Differentiation: Techniques and Applications.Drug design, development and therapy · 2025Review
- Coupling Isotopic Shifts with Collision Cross-Section Measurements for Carbohydrate Characterization in High-Resolution Ion Mobility Separations.Analytical chemistry · 2023Article
- Decoding the Fucose Migration Product during Mass-Spectrometric analysis of Blood Group Epitopes.Angewandte Chemie (International ed. in English) · 2023Article
- RDD-HCD Provides Variable Fragmentation Routes Dictated by Radical Stability.Journal of the American Society for Mass Spectrometry · 2023Article
- Mechanistic Study into Free Radical-Activated Glycan Dissociations through Isotope-Labeled Cellobioses.Analytical chemistry · 2023Article
- Assessing the Use of Host-Guest Chemistry in Conjunction with Cyclic Ion Mobility Separations for the Linkage-Specific Characterization of Human Milk Oligosaccharides.International journal of mass spectrometry · 2023Article
- Review
- MS-based glycomics: An analytical tool to assess nervous system diseases.Frontiers in neuroscience · 2022Review
- Advanced tandem mass spectrometry in metabolomics and lipidomics-methods and applications.Analytical and bioanalytical chemistry · 2021Review
- Linkage Memory in Underivatized Protonated Carbohydrates.Journal of the American Society for Mass Spectrometry · 2021Article
- Free-Radical-Mediated Glycan Isomer Differentiation.Analytical chemistry · 2020Article
- Ultraviolet Photodissociation Mass Spectrometry for Analysis of Biological Molecules.Chemical reviews · 2020Review
- Top-Down Characterization of Denatured Proteins and Native Protein Complexes Using Electron Capture Dissociation Implemented within a Modified Ion Mobility-Mass Spectrometer.Analytical chemistry · 2020Article
- Resin and Magnetic Nanoparticle-Based Free Radical Probes for Glycan Capture, Isolation, and Structural Characterization.Analytical chemistry · 2019Article
- Chiral Differentiation of Non-Covalent Diastereomers Based on Multichannel Dissociation Induced by 213-nm Ultraviolet Photodissociation.Journal of the American Society for Mass Spectrometry · 2019Article
- Advancing Solutions to the Carbohydrate Sequencing Challenge.Journal of the American Chemical Society · 2019Review
- Cyclic Ion Mobility Mass Spectrometry Distinguishes Anomers and Open-Ring Forms of Pentasaccharides.Journal of the American Society for Mass Spectrometry · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Glycans are fundamental biological macromolecules, yet despite their prevalence and recognized importance, a number of unique challenges hinder routine characterization. The multiplicity of OH groups in glycan monomers easily afford branched structures and alternate linkage sites, which can result in isomeric structures that differ by minute details. Herein, radical chemistry is employed in conjunction with mass spectrometry to enable rapid, accurate, and high throughput identification of a challenging series of closely related glycan isomers. The results are compared with analysis by collision-induced dissociation, higher-energy collisional dissociation, and ultraviolet photodissociation (UVPD) at 213 nm. In general, collision-based activation struggles to produce characteristic fragmentation patterns, while UVPD and radical-directed dissociation (RDD) can distinguish all isomers. In the case of RDD, structural differentiation derives from radical mobility and subsequent fragmentation. For glycans, the energetic landscape for radical migration is flat, increasing the importance of the three-dimensional structure. RDD is therefore a powerful and straightforward method for characterizing glycan isomers.
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Registered trials
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