ArticleLiver international : official journal of the International Association for the Study of the Liver2019
Parental non-alcoholic fatty liver disease increases risk of non-alcoholic fatty liver disease in offspring.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Updates on paediatric MASLD: insights from an endocrine lens.Diabetologia · 2026Review
- Quick glance at 'metabolic dysfunction associated steatotic liver disease' therapeutics: Targets, trials, and trends.World journal of gastrointestinal pharmacology and therapeutics · 2025Review
- The contribution of genetics and epigenetics to MAFLD susceptibility.Hepatology international · 2024Review
- The effects of weight loss interventions on children and adolescents with non-alcoholic fatty liver disease: A systematic review and meta-analysis.Obesity science & practice · 2024Review
- Maternal gestational hypertension, smoking and pre-eclampsia are associated with metabolic dysfunction-associated fatty liver disease in overweight offspring.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Parental History of Type 2 Diabetes Mellitus and PNPLA3 Polymorphism Increase the Risk of Severe Stages of Nonalcoholic Fatty Liver Disease.Digestive diseases and sciences · 2024Article
- Development and Validation of the Nonalcoholic Fatty Liver Disease Familial Risk Score to Detect Advanced Fibrosis: A Prospective, Multicenter Study.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
- Parental metabolic syndrome and elevated liver transaminases are risk factors for offspring, even in children and adolescents with a normal body mass index.Frontiers in nutrition · 2023Article
- Risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease.The Journal of clinical investigation · 2022Article
- Non-alcoholic fatty liver disease and the impact of genetic, epigenetic and environmental factors in the offspring.World journal of gastroenterology · 2022Review
- Factors early in life associated with hepatic steatosis.World journal of hepatology · 2022Article
- Effect of cofactors on NAFLD/NASH and MAFLD. A paradigm illustrating the pathomechanics of organ dysfunction.Metabolism and target organ damage · 2022Article
- Nutrigenomics and Nutrigenetics in Metabolic- (Dysfunction) Associated Fatty Liver Disease: Novel Insights and Future Perspectives.Nutrients · 2021Review
- Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors.International journal of environmental research and public health · 2021Review
- Genetic Contribution to Non-alcoholic Fatty Liver Disease and Prognostic Implications.Current diabetes reports · 2021Review
- Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes.Journal of hepatology · 2020Article
- Physical exercise and liver "fitness": Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease.Molecular metabolism · 2020Review
- Novel Insights into the Genetic Landscape of Nonalcoholic Fatty Liver Disease.International journal of environmental research and public health · 2019Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsLittle is known regarding the risk of hepatic steatosis (HS) among adult children of affected parents. We examined the association between parental and offspring HS in the multigenerational Framingham Heart Study, which characterized HS using computed tomography.
methodsWe performed multivariable logistic regression models adjusted for age, sex, alcohol use, and body mass index to generate the odds of HS according to parental HS. We determined the proportion of participants with HS according to parental HS and the presence or absence of hypertension, diabetes, or obesity (BMI ≥30 kg/m
resultsApproximately 23% (183/785) had at least one parent with HS and 1.1% had two affected parents (9/785). In adjusted models, participants with at least one parent with HS had a nearly two-fold increased odds of HS compared to participants without a parental history of HS (OR 1.86, 95% confidence interval 1.15-3.03). Among participants without hypertension, diabetes, or obesity, a higher proportion had HS if they had a parental history of HS compared to those without (16.1% vs 5.2%, P < 0.001). However, for participants with cardiometabolic risk factors, we did not observe a difference in HS among those with and without parental HS (30.3% vs 28.5%, P = 0.78).
conclusionsIndividuals with a parental history of HS are at increased risk for HS. Specifically, a parental history of HS may be an important factor among those that are otherwise metabolically healthy.
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