Evidence map›Paper›PMID 30179230›Full record

ArticleScientific data2018

Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy.

Aaron J Grossberg, Abdallah S R Mohamed, Hesham Elhalawani, William C Bennett, Kirk E Smith, Tracy S Nolan, Bowman Williams, Sasikarn Chamchod, Jolien Heukelom, Michael E Kantor and 9 more

Erratum issuedAbstract readDataset
In one paragraph

Article in Scientific data, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. The impact of scanner domain shift on deep learning performance in medical imaging: an experimental study.International journal of computer assisted radiology and surgery · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Aaron J GrossbergDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.ORCID 0000-0003-4690-4948
Abdallah S R MohamedDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.ORCID 0000-0003-2064-7613
Hesham ElhalawaniDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
William C BennettDepartment of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Kirk E SmithDepartment of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Tracy S NolanDepartment of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Bowman WilliamsDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Sasikarn ChamchodDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Jolien HeukelomDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Michael E KantorDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Theodora BrowneDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Katherine A HutchesonDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
G Brandon GunnDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Adam S GardenDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
William H MorrisonDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Steven J FrankDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
David I RosenthalDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
John B FreymannLeidos Biomedical Research, Inc. Frederick National Laboratory for Cancer Research, Frederick, Maryland 20892, USA.
Clifton D FullerDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.ORCID 0000-0002-5264-3994

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Targeting the p53 pathway for reversal of oral premalignancyP50CA097007 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILLS, GORDON B. · 2002 to 2012
$26.1M
Paul Calabresi Clinical Oncology AwardK12CA088084 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI David S. Hong, Scott Kopetz · 2000 to 2026
$14.0M
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular OsteoradionecrosisR01DE025248 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LAI, STEPHEN Y · 2016 to 2020
$2.9M
Resources for development and validation of Radiomic analyses & Adaptive TherapyU01CA187013 · NCI · WASHINGTON UNIVERSITY · PI PRIOR, FRED WILLIAM, SHARMA, ASHISH · 2014 to 2018
$2.6M
SMART-ACT: Spatial Methodologic Approaches for Risk Assessment and Therapeutic Adaptation in Cancer TreatmentR01CA214825 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CANAHUATE, GUADALUPE, FULLER, CLIFTON DAVID · 2017 to 2019
$1.1M
NCI NIH HHS K12 CA088084NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA097007NCI NIH HHS R01 CA214825NCI NIH HHS U01 CA187013NIDCR NIH HHS R01 DE025248
6 · The paper itself

Abstract

Cross sectional imaging is essential for the patient-specific planning and delivery of radiotherapy, a primary determinant of head and neck cancer outcomes. Due to challenges ensuring data quality and patient de-identification, publicly available datasets including diagnostic and radiation treatment planning imaging are scarce. In this data descriptor, we detail the collection and processing of computed tomography based imaging in 215 patients with head and neck squamous cell carcinoma that were treated with radiotherapy. Using cross sectional imaging, we calculated total body skeletal muscle and adipose content before and after treatment. We detail techniques for validating the high quality of these data and describe the processes of data de-identification and transfer. All imaging data are subject- and date-matched to clinical data from each patient, including demographics, risk factors, grade, stage, recurrence, and survival. These data are a valuable resource for studying the association between patient-specific anatomic and metabolic features, treatment planning, and oncologic outcomes, and the first that allows for the integration of body composition as a risk factor or study outcome.

Indexed as

Head and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckHumansImage Processing, Computer-AssistedTomography, X-Ray Computed

Identifiers

PMID30179230
PMCPMC6190723

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.