ArticleRadiology2018
Lung Adenocarcinoma: CT Features Associated with Spread through Air Spaces.
Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.
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Who cites it
92 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Analysis of Individual Patient Data Demonstrates that Sublobar Resection Followed by Adjuvant Chemotherapy has Equivalent Prognosis to Lobectomy in Patients with Stage I NSCLC with Spread through Air Spaces.Annals of surgical oncology · 2026Pooled it
- The prognostic significance of tumor spread through air space in stage I lung adenocarcinoma.Thoracic cancer · 2022Pooled it
- Meta-analysis of association between CT-based features and tumor spread through air spaces in lung adenocarcinoma.Journal of cardiothoracic surgery · 2020Pooled it
- Nomogram based on clinical characteristics and radiological features for the preoperative prediction of spread through air spaces in patients with clinical stage IA non-small cell lung cancer: a multicenter study.Diagnostic and interventional radiology (Ankara, Turkey) · 2023Trial
- Peritumoral radiomics features on preoperative thin-slice CT images can predict the spread through air spaces of lung adenocarcinoma.Scientific reports · 2022Trial
- Spread through air spaces as a marker of nonlinear evolutionary trajectories in lung cancer: implications for the 9th edition TNM classification.Journal of pathology and translational medicine · 2026Article
- Dual-layer spectral CT for predicting spread through air spaces in lung adenocarcinoma: a dual-center study.European radiology · 2026Article
- Tumor Spread through Air Spaces in Early-Stage Lung Adenocarcinoma: Surgical Implications and Patient Management Strategies.Journal of chest surgery · 2026Review
- Machine learning-based preoperative prediction of spread through air spaces in clinical stage IA non-small cell lung cancer: a single-center study integrating clinical and CT imaging characteristics.Journal of thoracic disease · 2026Article
- The clinicoradiological and pathological-molecular characteristics associated with spread through air spaces in stage IA invasive lung adenocarcinoma.Insights into imaging · 2026Article
- Observational
- Predicting STAS in peripheral stage I lung adenocarcinoma: the incremental value of CT-based tumor disappearance rate, with a focus on part-solid nodules.BMC medical imaging · 2026Article
- STAS More than a Prognostic Marker-An Evolving Factor in Operative and Adjuvant Treatment Decisions in Early-Stage NSCLC.Cancers · 2026Review
- Imaging advances of predicting spread through air spaces (STAS) in lung cancer: a narrative review.Journal of thoracic disease · 2026Review
- Computed tomography-based tumoral and peritumoral radiomics models for preoperative prediction of the spread through air spaces in patients with clinical stage I pure solid invasive lung adenocarcinoma: a multicenter study.Journal of thoracic disease · 2026Article
- Article
- Machine learning-based quantitative prediction of spread through air spaces in primary lung adenocarcinoma using intratumoural heterogeneity scores.International journal of surgery (London, England) · 2025Article
- Multidisciplinary Perspective of Spread Through Air Spaces in Lung Cancer: A Narrative Review.Cancers · 2025Review
- Prediction of STAS positivity in operable non-small cell lung cancer.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Joint model based on intratumoral and peritumoral computed tomography radiomics integrated with clinical features for predicting the spread through air spaces in lung adenocarcinoma: a multicenter study.Quantitative imaging in medicine and surgery · 2025Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose To identify the features at CT that are predictive of spread through air spaces (STAS) in surgically resected lung adenocarcinomas. Materials and Methods For this retrospective study, presence of STAS was evaluated in 948 consecutive patients who underwent surgical resection for lung adenocarcinoma from April 2015 to December 2016. Patients who were positive for STAS and negative for STAS were matched at a ratio of 1:2 by using patient variables (age, sex, and smoking status). CT features (ie, percentage of solid component, maximum diameter of solid component, lesion density, location, margin, shape, pseudocavity, calcification, central low attenuation, ill-defined peripheral opacity, air bronchogram, satellite lesions, and pleural retraction) were analyzed by using multivariable logistic regression and receiver operating characteristic curves. Results The final study population consisted of 276 patients (mean age, 59 years; age range, 32-78 years) including 129 men (mean age, 60 years; age range, 36-78 years) and 147 women (mean age, 59 years; age range, 32-78 years). Ninety-two patients were positive for STAS and 184 patients were negative for STAS. STAS was more common in solid tumors (71 of 92; 77%) than in part-solid (21 of 92; 23%) or ground-glass lesions (0 of 92; 0%) (P < .001). STAS was also associated with central low attenuation, ill-defined opacity, air bronchogram, and percentage of solid component (all P < .001). Percentage of solid component was an independent predictor of STAS (odds ratio, 1.06; 95% confidence interval: 1.03, 1.08) and a cut-off value of 90% showed a discriminatory power with a sensitivity of 89.2% and a specificity of 60.3%. Conclusion Percentage of solid component was independently associated with spread through air spaces in lung adenocarcinomas. © RSNA, 2018 Online supplemental material is available for this article.
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