Evidence map›Paper›PMID 30178793›Full record

ArticleDalton transactions (Cambridge, England : 2003)2018

A comprehensively revised strategy that improves the specific activity and long-term stability of clinically relevant

Nikunj B Bhatt, Darpan N Pandya, Stephanie Rideout-Danner, Howard D Gage, Frank C Marini, Thaddeus J Wadas

Open access · greenAbstract read
In one paragraph

Article in Dalton transactions (Cambridge, England : 2003), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. The Evaluation of (1Molecules (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Biodistribution ofACS omega · 2025
    Article
  5. Article
  6. Article
  7. Polyazamacrocycle Ligands FacilitateInorganic chemistry · 2020
    Article
  8. Article
  9. Article
  10. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nikunj B BhattDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. twadas@wakehealth.edu.
Darpan N PandyaDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. twadas@wakehealth.edu.ORCID http://orcid.org/0000-0001-6288-5172
Stephanie Rideout-DannerDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Howard D GageDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.ORCID http://orcid.org/0000-0002-4352-2146
Frank C MariniDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. twadas@wakehealth.edu and Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC 27157, USA.
Thaddeus J WadasDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. twadas@wakehealth.edu.ORCID http://orcid.org/0000-0002-9913-0336
Winston-Salem/Forsyth County Schools · USForest Institute · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
PET Imaging of the Tumor Microenvironment for Cancer DetectionR21CA219899 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WADAS, THADDEUS J. · 2018 to 2019
$366k
NCATS NIH HHS UL1 TR001420NCI NIH HHS P30 CA012197NCI NIH HHS R21 CA219899
6 · The paper itself

Abstract

Zirconium-89 is currently being used in numerous clinical trials involving monoclonal antibodies and positron emission tomography. This report describes a revised strategy that reduces preparation time while increasing the specific activity of clinically relevant immuno-PET agents. Additionally, it demonstrates that n-acetyl-l-cysteine acts as a superior radioprotective agent that improves long-term stability without compromising antigen affinity in vivo.

Identifiers

PMID30178793
PMCPMC6192516
OpenAlexW2890223314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.