Evidence map›Paper›PMID 30178632›Full record

ArticleActa ophthalmologica2018

A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes.

Weihua Meng, Kaanan P Shah, Samuela Pollack, Iiro Toppila, Harry L Hebert, Mark I McCarthy, Leif Groop, Emma Ahlqvist, Valeriya Lyssenko, Elisabet Agardh and 31 more

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In one paragraph

Article in Acta ophthalmologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  4. Article
  5. Higher diabetes genetic load in proliferative diabetic retinopathy in South India: The South Indian GeNetics of DiAbeTic Retinopathy (SIGNATR) study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

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5 · Who and what money

Authors and funding

41 authors.

Weihua MengDivision of Population Health Sciences, Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0001-5388-8494
Kaanan P ShahSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Samuela PollackDepartment of Epidemiology, Harvard T.H., Chan School of Public Health, Boston, Massachusetts, USA.
Iiro ToppilaFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Harry L HebertDivision of Population Health Sciences, Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, UK.
Mark I McCarthyOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, UK.
Leif GroopDepartment of Clinical Sciences, Faculty of Medicine, Lund University, Malmo, Sweden.
Emma AhlqvistDepartment of Clinical Sciences, Faculty of Medicine, Lund University, Malmo, Sweden.
Valeriya LyssenkoDepartment of Clinical Sciences, Faculty of Medicine, Lund University, Malmo, Sweden.
Elisabet AgardhDepartment of Clinical Sciences, Faculty of Medicine, Lund University, Malmo, Sweden.
Mark DaniellDepartment of Ophthalmology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Georgia KaidonisDepartment of Ophthalmology, Flinders University, Adelaide, South Australia, Australia.
Jamie E CraigDepartment of Ophthalmology, Flinders University, Adelaide, South Australia, Australia.
Paul MitchellCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney C24, Sydney, Australia.
Gerald LiewCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney C24, Sydney, Australia.
Annette KifleyCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney C24, Sydney, Australia.
Jie Jin WangCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney C24, Sydney, Australia.
Mark W ChristiansenCardiovascular Health Research Unit, School of Medicine, University of Washington, Seattle, Washington, USA.
Richard A JensenCardiovascular Health Research Unit, School of Medicine, University of Washington, Seattle, Washington, USA.
Alan PenmanDepartment of Ophthalmology, University of Mississippi Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA.
Heather A HancockDepartment of Ophthalmology, University of Mississippi Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA.
Ching J ChenDepartment of Ophthalmology, University of Mississippi Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA.
Adolfo CorreaDepartment of Ophthalmology, University of Mississippi Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA.
Jane Z KuoClinical and Medical Affairs, CardioDx Inc., Redwood City, California, USA.
Xiaohui LiInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, USA.
Yii-der I ChenInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, USA.
Ronald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Barbara KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Tien Y WongSingapore Eye Research Institute, Singapore National Eye Centre, Yong Loo Lin School of Medicine, National University of Singapore, Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore.
Andrew D MorrisThe Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Alexander S F DoneyMedical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, UK.
Helen M ColhounInstitute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Alkes L PriceDepartment of Epidemiology, Harvard T.H., Chan School of Public Health, Boston, Massachusetts, USA.
Kathryn P BurdonDepartment of Ophthalmology, Flinders University, Adelaide, South Australia, Australia.
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Niina SandholmFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Michael A GrassiDepartment of Ophthalmology, University of Illinois at Chicago, Chicago, Illinois, USA.
Lucia SobrinDepartment of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
Colin N A PalmerCentre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, UK.
Wellcome Trust Case Control Consortium 2 (WTCCC2), Surrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT) study groupDivision of Population Health Sciences, Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, UK.

Funding

Mass Eye and Ear-Vision Clinical Scientist Development ProgramK12EY016335 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Reza Dana · 2004 to 2026
$12.3M
Multi-ethnic GWAS of diabetic retinopathy: enhanced power using new methodsR01EY022302 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI SOBRIN, LUCIA · 2012 to 2014
$918k
Medical Research Council MC_PC_13040NEI NIH HHS K12 EY016335NEI NIH HHS R01 EY022302
6 · The paper itself

Abstract

purposeDiabetic retinopathy is the most common eye complication in patients with diabetes. The purpose of this study is to identify genetic factors contributing to severe diabetic retinopathy.

methodsA genome-wide association approach was applied. In the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) datasets, cases of severe diabetic retinopathy were defined as type 2 diabetic patients who were ever graded as having severe background retinopathy (Level R3) or proliferative retinopathy (Level R4) in at least one eye according to the Scottish Diabetic Retinopathy Grading Scheme or who were once treated by laser photocoagulation. Controls were diabetic individuals whose longitudinal retinopathy screening records were either normal (Level R0) or only with mild background retinopathy (Level R1) in both eyes. Significant Single Nucleotide Polymorphisms (SNPs) were taken forward for meta-analysis using multiple Caucasian cohorts.

resultsFive hundred and sixty cases of type 2 diabetes with severe diabetic retinopathy and 4,106 controls were identified in the GoDARTS cohort. We revealed that rs3913535 in the NADPH Oxidase 4 (NOX4) gene reached a p value of 4.05 × 10

conclusionThis genome-wide association study of severe diabetic retinopathy suggests new evidence for the involvement of the NOX4 gene.

Indexed as

Polymorphism, Single NucleotideAdultDiabetes Mellitus, Type 2Diabetic RetinopathyFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotyping TechniquesHumansLaser CoagulationMaleMiddle AgedNADPH Oxidase 4ScotlandWhite PeopleNADPH Oxidase 4NOX4 protein, humandiabetesdiabetic complicationsdiabetic retinopathygenome-wide association studyNOX4

Identifiers

PMID30178632
PMCPMC6263819

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