Evidence map›Paper›PMID 30178370›Full record

ArticleAdvances in experimental medicine and biology

Long-Term In Vivo Oxygen Sensors for Peripheral Artery Disease Monitoring.

Scott P Nichols, Mary K Balaconis, Rebecca M Gant, Kit Y Au-Yeung, Natalie A Wisniewski

Registry-linked trialAbstract read
In one paragraph

Article in Advances in experimental medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04514861 (Effectiveness of Measuring Local Tissue Oxygen in Response to Induced Hemodynamic Changes With the Profusa's Wireless Lumee Oxygen Platform in Patients With Peripheral Artery Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04514861 naactive not recruitingnot on this map

Effectiveness of Measuring Local Tissue Oxygen in Response to Induced Hemodynamic Changes With the Profusa's Wireless Lumee Oxygen Platform in Patients With Peripheral Artery Disease (PAD)

TypeinterventionalSponsorProfusa, Inc.Ran2020 to 2028Enrolled53ConditionsPeripheral Artery DiseaseArmsWireless Lumee Oxygen Platform
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Scott P NicholsProfusa, Inc., College Station, TX, USA. scott.nichols@profusa.com.
Mary K BalaconisProfusa, Inc., College Station, TX, USA.
Rebecca M GantProfusa, Inc., College Station, TX, USA.
Kit Y Au-YeungProfusa, Inc., South San Francisco, CA, USA.
Natalie A WisniewskiProfusa, Inc., South San Francisco, CA, USA.

Funding

Implantable multi-analyte sensors for the continuous monitoring of body chemistriR01EB016414 · NIBIB · PROFUSA, INC. · PI MCSHANE, MIKE, WISNIEWSKI, NATALIE ANN · 2012 to 2015
$4.9M
Real-Time Oxygen Monitoring for Tissue Health: Peripheral Artery Disease ApplicationR42HL127933 · NHLBI · PROFUSA, INC. · PI NICHOLS, SCOTT · 2015 to 2017
$2.0M
Tissue Oxygen Monitoring in Peripheral Vascular DiseaseR44HL131366 · NHLBI · PROFUSA, INC. · PI CONTE, MICHAEL S, REBRIN, KERSTIN · 2016 to 2019
$1.7M
Wearable Patch Reader for Peripheral Artery DiseaseR44HL134532 · NHLBI · PROFUSA, INC. · PI REGISTER, JANNA · 2016 to 2017
$1.5M
NHLBI NIH HHS R42 HL127933NHLBI NIH HHS R44 HL131366NHLBI NIH HHS R44 HL134532NIBIB NIH HHS R01 EB016414
6 · The paper itself

Abstract

Tracking of tissue oxygenation around chronic foot wounds may help direct therapy decisions in patients with peripheral artery disease (PAD). Novel sensing technology to enable such monitoring was tested over 9 months in a Sinclair mini-pig model. No adverse events were observed over the entire study period. Systemic and acute hypoxia challenges were detected during each measurement period by the microsensors. The median time to locate the sensor signal was 13 s. Lumee Oxygen microsensors appear safe for long-term repeated oxygen measurements over 9 months.

Indexed as

Biosensing TechniquesPeripheral Arterial DiseaseAnimalsHydrogel, Polyethylene Glycol DimethacrylateOxygenSwineSwine, MiniatureHydrogel, Polyethylene Glycol DimethacrylateOxygen

Identifiers

PMID30178370
PMCPMC6367927

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.