ArticleAdvances in experimental medicine and biology2018
A Fibreless Multiwavelength NIRS System for Imaging Localised Changes in Cerebral Oxidised Cytochrome C Oxidase.
Article in Advances in experimental medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Quantitative assessment of cytochrome C oxidase patterns in muscle tissue by the use of near-infrared spectroscopy (NIRS) in healthy volunteers.Journal of clinical monitoring and computing · 2022Trial
- Advances in fully integrated wearable near-infrared spectroscopy: hardware innovations and biomedical applications.JPhys photonics · 2026Review
- Investigating the effect of limited spectral information on NIRS-derived changes in hemoglobin and cytochrome-c-oxidase concentration with a diffusion-based model.Biomedical optics express · 2024Article
- Review of measurements and imaging of cytochrome-c-oxidase in humans using near-infrared spectroscopy: an update.Biomedical optics express · 2024Review
- Parallel factor analysis for multidimensional decomposition of functional near-infrared spectroscopy data.Neurophotonics · 2022Article
- High-density diffuse optical tomography for imaging human brain function.The Review of scientific instruments · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Measurement of the oxidation state of cytochrome c oxidase (oxCCO) can inform directly on neuronal metabolism. Conventionally this has been measured in vivo using benchtop broadband near infrared spectroscopy (NIRS) systems. Spatially resolved measures of oxCCO have recently been made possible using a multichannel fibre-based broadband NIRS system. We describe the use of a fibreless multiwavelength NIRS system using light emitting diodes (LED) designed specifically to image localised changes in oxCCO and hence neuronal metabolism. A fibreless system consisting of four modules, each containing two LED sources and four photodiode detectors, was developed. Each LED source contained eight LED dies (780, 811, 818, 842, 850, 882, 891 and 901 nm) assembled in an area of 1.5 × 1.5 mm. A well-established hyperoxia protocol was used to evaluate the oxCCO spatially resolved measurement capabilities of the system and, subsequently, its imaging capabilities were tested using a functional activation paradigm. A multi-spectral image reconstruction approach was used to provide images of Δ[HbO
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