Evidence map›Paper›PMID 30178296›Full record

ArticleMolecular neurobiology2019

Altered Expression of Umbilical Cord Blood Levels of miR-181b and Its Downstream Target mUCH-L1 in Infants with Moderate and Severe Neonatal Hypoxic-Ischaemic Encephalopathy.

A M Looney, M P O'Sullivan, C E Ahearne, M Finder, U Felderhoff-Mueser, G B Boylan, B Hallberg, Deirdre M Murray

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04816331 (Follow-up of Inflammatory Responses and Multiorgan Outcomes FoLlowing Neonatal Brain injurY), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04816331 unknown statusnot on this mapstarted 2020, after this paper: background citation

Follow-up of Inflammatory Responses and Multiorgan Outcomes FoLlowing Neonatal Brain injurY

Typeobservational_patient_registrySponsorUniversity of Dublin, Trinity CollegeRan2020 to 2022Enrolled200ConditionsNeonatal EncephalopathyArmsMedical records and clinical measurements
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Observational
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

A M LooneyDepartment of Paediatrics and Child Health, University College Cork, Cork, Ireland.
M P O'SullivanDepartment of Paediatrics and Child Health, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0002-6184-3306
C E AhearneDepartment of Paediatrics and Child Health, University College Cork, Cork, Ireland.
M FinderPediatric Department, CLINTEC, Karolinska Institutet and Neonatal Department, Karolinska University Hospital, Stockholm, Sweden.
U Felderhoff-MueserDepartment of Pediatrics/Neonatology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
G B BoylanDepartment of Paediatrics and Child Health, University College Cork, Cork, Ireland.
B HallbergPediatric Department, CLINTEC, Karolinska Institutet and Neonatal Department, Karolinska University Hospital, Stockholm, Sweden.
Deirdre M MurrayDepartment of Paediatrics and Child Health, University College Cork, Cork, Ireland. d.murray@ucc.ie.
University College Cork · IEKarolinska University Hospital · SEUniversity of Duisburg-Essen · DE

Funding

Health Research Board HRB; CSA/2012/40National Children's Research Centre, Crumlin NCRC B/14/1Science Foundation Ireland INFANT-12/RC/2272
6 · The paper itself

Abstract

Hypoxic-ischaemic encephalopathy (HIE) remains one of the leading causes of neurological disability worldwide. No blood biomarker capable of early detection and classification of injury severity in HIE has been identified. This study aimed to investigate the potential of miRNA-181b (miR-181b) and its downstream target, ubiquitin C-terminal hydrolase-L1 (UCH-L1), to predict the severity of HIE. Full-term infants with perinatal asphyxia were recruited at birth and observed for the development of HIE, along with healthy controls. Levels of miR-181b and messenger UCH-L1 (mUCH-L1) in umbilical cord blood were determined using qRT-PCR. In total, 131 infants; 40 control, 50 perinatal asphyxia without HIE (PA) and 41 HIE, recruited across two separate cohorts (discovery and validation) were included in this study. Significant and consistent downregulation of miR-181b was observed in infants with moderate/severe HIE compared to all other groups in both cohorts: discovery 0.25 (0.16-0.32) vs 0.61 (0.26-1.39), p = 0.027 and validation 0.33 (0.15-1.78) vs 1.2 (0.071-2.09), p = 0.035. mUCH-L1 showed increased expression in infants with HIE in both cohorts. The expression ratio of miR-181b to mUCH-L1 was reduced in those infants with moderate/severe HIE in both cohorts: discovery cohort 0.23 (0.06-0.44) vs 1.59 (0.46-2.54), p = 0.01 and validation cohort 0.41 (0.10-0.81) vs 1.38 (0.59-2.56) in all other infants, p = 0.009. We have validated consistent patterns of altered expression in miR-181b/mUCH-L1 in moderate/severe neonatal HIE which may have the potential to guide therapeutic intervention in HIE.

Indexed as

Cohort StudiesFemaleGene Expression RegulationHumansHypoxia-Ischemia, BrainInfant, NewbornMaleMicroRNAsReproducibility of ResultsRNA, MessengerUbiquitin ThiolesteraseMicroRNAsMIrn181 microRNA, humanRNA, MessengerUbiquitin ThiolesteraseUCHL1 protein, humanBiomarkerHypoxic-ischaemic encephalopathy|miR-181bmiRNAPerinatal asphyxiaUCHL1

Identifiers

PMID30178296
OpenAlexW2891039026

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.