Evidence map›Paper›PMID 30178286›Full record

ArticleDigestive diseases and sciences2018

A New Look at Familial Risk of Inflammatory Bowel Disease in the Ashkenazi Jewish Population.

Elena R Schiff, Matthew Frampton, Francesca Semplici, Stuart L Bloom, Sara A McCartney, Roser Vega, Laurence B Lovat, Eleanor Wood, Ailsa L Hart, Daniel Crespi and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Saudi consensus guidance for the management of inflammatory bowel disease during pregnancy.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Elena R SchiffCentre for Molecular Medicine, Division of Medicine, University College London, London, UK. e.schiff@ucl.ac.uk.
Matthew FramptonCentre for Molecular Medicine, Division of Medicine, University College London, London, UK.
Francesca SempliciCentre for Molecular Medicine, Division of Medicine, University College London, London, UK.
Stuart L BloomDepartment of Gastroenterology, University College London Hospital, London, UK.
Sara A McCartneyDepartment of Gastroenterology, University College London Hospital, London, UK.
Roser VegaDepartment of Gastroenterology, University College London Hospital, London, UK.
Laurence B LovatDepartment of Gastroenterology, University College London Hospital, London, UK.
Eleanor WoodGastroenterology Department, Homerton University Hospital, London, UK.
Ailsa L HartGastroenterology Department, St Mark's Hospital, London, UK.
Daniel CrespiCentre for Paediatric Gastroenterology, Royal Free Hospital, London, UK.
Mark A FurmanCentre for Paediatric Gastroenterology, Royal Free Hospital, London, UK.
Steven MannGastroenterology Department, Barnet General Hospital, London, UK.
Charles D MurrayCentre for Gastroenterology, Royal Free Hospital, London, UK.
Anthony W SegalCentre for Molecular Medicine, Division of Medicine, University College London, London, UK.
Adam P LevineCentre for Molecular Medicine, Division of Medicine, University College London, London, UK.
University College London · GBUniversity College Hospital · GBThe Royal Free Hospital · GBBarnet Hospital · GBHomerton University Hospital · GBSt Mark's Hospital · GB

Funding

Medical Research Council
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe inflammatory bowel diseases (IBD) are particularly common among the Ashkenazi Jewish (AJ) population. Population-specific estimates of familial risk are important for counseling; however, relatively small cohorts of AJ IBD patients have been analyzed for familial risk to date. This study aimed to recruit a new cohort of AJ IBD patients, mainly from the UK, to determine the familial occurrence of disease.

methodsA total of 864 AJ IBD patients were recruited through advertisements, hospital clinics, and primary care. Participants were interviewed about their Jewish ancestry, disease phenotype, age of diagnosis, and family history of disease. Case notes were reviewed.

resultsThe 864 probands comprised 506 sporadic and 358 familial cases, the latter with a total of 625 affected relatives. Of the UK cases, 40% had a positive family history with 25% having at least one affected first-degree relative. These percentages were lower among those recruited through hospital clinics and primary care (33% for all relatives and 22% among first-degree relatives). Examining all probands, the relative risk of IBD for offspring, siblings, and parents was 10.5, 7.4, and 4, respectively. Age of diagnosis was significantly lower in familial versus sporadic patients with Crohn's disease.

conclusionsThis study reports familial risk estimates for a significant proportion of the AJ IBD population in the UK. The high rate of a positive family history in this cohort may reflect the greater genetic burden for IBD among AJs. These data are of value in predicting the likelihood of future recurrence of IBD in AJ families.

Indexed as

AdultAge of OnsetCohort StudiesHumansInflammatory Bowel DiseasesUnited KingdomYoung AdultAshkenazi JewishEpidemiologyFamilial riskInflammatory bowel disease

Identifiers

PMID30178286
PMCPMC6182437
OpenAlexW2889722253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.