ArticleNeuromolecular medicine2019
Variants of the OLIG2 Gene are Associated with Cerebral Palsy in Chinese Han Infants with Hypoxic-Ischemic Encephalopathy.
Article in Neuromolecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Association between Cu/Zn/Iron/Ca/Mg levels and cerebral palsy: a pooled-analysis.Scientific reports · 2023Pooled it
- Birth Asphyxia Is Associated With Increased Risk of Cerebral Palsy: A Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction.Open medicine (Warsaw, Poland) · 2024Article
- Maternal and Fetal Risk Factors for Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Study.International journal of general medicine · 2023Article
- Association of Nogo-A Gene Polymorphisms with Cerebral Palsy in Southern China: A Case-Control Study.Developmental neuroscience · 2023Article
- Article
- An association study of IL2RA polymorphisms with cerebral palsy in a Chinese population.BMC medical genomics · 2022Article
- Genetic Polymorphisms, Gene-Gene Interactions and Neurologic Sequelae at Two Years Follow-Up in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- Prognostic value of amplitude-integrated EEG in neonates with high risk of neurological sequelae.Annals of clinical and translational neurology · 2020Article
- The Association Study ofFrontiers in neuroscience · 2020Article
- Iron Metabolism and Brain Development in Premature Infants.Frontiers in physiology · 2019Review
- Autophagy-Related Gene 7 Polymorphisms and Cerebral Palsy in Chinese Infants.Frontiers in cellular neuroscience · 2019Article
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Cerebral palsy (CP) is a leading cause of neurological disability among young children. Congenial and adverse perinatal clinical conditions, such as genetic factors, perinatal infection, and asphyxia, are risk factors for CP. Oligodendrocyte transcription factor (OLIG2) is a protein that is expressed in brain oligodendrocyte cells and is involved in neuron repair after brain injury. In this study, we employed a Chinese Han cohort of 763 CP infants and 738 healthy controls to study the association of OLIG2 gene polymorphisms with CP. We found marginal association of the SNP rs6517135 with CP (p = 0.044) at the genotype level, and the association was greatly strengthened when we focused on the subgroup of CP infants who suffered from hypoxic-ischemic encephalopathy (HIE) after birth, with p = 0.003 (OR = 0.558) at the allele level and p = 0.007 at the genotype level, indicating a risk-associated role of the T allele of the SNP rs6517135 under HIE conditions. The haplotype CTTG for rs6517135-rs1005573-rs6517137-rs9653711 in OLIG2 was also significantly associated with the occurrence of CP in infants with HIE (p = 0.01, OR = 0.521). Our results indicate that in the Han Chinese population, the polymorphisms of OLIG2 were associated with CP, especially in patients who had suffered HIE injury. This finding could be used to develop personalized care for infants with high susceptibility to CP.
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