ArticleClinical rheumatology2018
Validity of the central sensitization inventory with measures of sensitization in people with knee osteoarthritis.
Article in Clinical rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Relationship Between Central Sensitization and Disability in Patients With Chronic Musculoskeletal Pain in Physical Medicine and Rehabilitation Clinic.
Effects of Central Sensitization on Response to Conventional Physical Therapy in Patients With Knee Osteoarthritis
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- CSI and Musculoskeletal Pain: Clinical Validity and Neurophysiological Implications.Current pain and headache reports · 2025Pooled it
- Tests for central sensitization in general practice: a Delphi study.BMC family practice · 2021Pooled it
- High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression.CartilagePooled it
- The impacts of transcranial direct current stimulation combined with aquatic neuromuscular training on pain, function, kinesiophobia, knee instability, and quality of life in knee osteoarthritis: a double-blind randomized trial.Journal of neuroengineering and rehabilitation · 2025Trial
- The effect of balance exercises on central sensitization in patients with knee osteoarthritis.Rheumatology international · 2024Trial
- Trial
- Regional vs global physical therapy interventions to treat chronic pain in survivors of trauma: a randomized controlled trial.The Journal of manual & manipulative therapy · 2023Trial
- Review
- Prevalence and Association of Neuropathic Pain and Central Sensitization in Participants with Knee Osteoarthritis: Establishing a Cutoff Score for the Central Sensitization Inventory.Journal of pain research · 2026Article
- The importance of central sensitization for clinical trials of disease modifying osteoarthritis drugs (DMOADs).Osteoarthritis imaging · 2025Article
- Applying Nociplastic Pain Criteria in Chronic Musculoskeletal Conditions: A Vignette Study.Journal of clinical medicine · 2025Article
- Explaining persistent physical symptoms to patients in general practice: can tests to measure central sensitisation add value? A mixed-methods study.BMC primary care · 2024Article
- Does pain intensity after total knee arthroplasty depend on somatosensory functioning in knee osteoarthritis patients? A prospective cohort study.Clinical rheumatology · 2024Article
- Limited content overlap between commonly used self-report instruments for central (pain) sensitization in rheumatology.Rheumatology advances in practice · 2024Article
- The effect of human assumed central sensitization on transforaminal epidural steroid injection in chronic lumbar radiculopathy: An observational study.Journal of back and musculoskeletal rehabilitation · 2024Observational
- Central sensitization negatively influences the level of disability in female patients with anterior knee pain.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- The relation of psychological status and type D personality with central sensitization in knee osteoarthritis: everything is in your mind!Rheumatology international · 2023Article
- Low central sensitisation inventory score is associated with better post-operative outcomes of osteotomy around the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Impact of central sensitization on pain, disability and psychological distress in patients with knee osteoarthritis and chronic low back pain.BMC musculoskeletal disorders · 2023Article
- Demographic predictors of central sensitization in patients of knee osteoarthritis.Journal of family medicine and primary care · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Our purpose was to determine the validity of the Central Sensitization Inventory (CSI) with psychophysical tests, psychological and physical factors in patients with Knee Osteoarthritis (KOA). Patients with KOA were recruited from three Montreal hospitals. Psychophysical tests (pressure pain threshold, conditioned pain modulation, temporal summation) were conducted and questionnaires administered to determine the presence of neuropathic pain, somatization, anxiodepressive symptoms, pain catastrophizing (PC), and widespread pain (WSP). Relations between the CSI, psychophysical tests, and questionnaires were assessed using correlations and chi-square analysis. Receiver Operating Characteristics (ROC) curves determined sensitivity and specificity scores. Multiple linear regression was performed to predict the association of CSI scores with somatization, anxiodepressive symptoms, PC, and WSP factors. One hundred thirty-three participants were assessed, 56.4% female, mean age 63.5 years. The CSI was weakly correlated with decreased pressure pain thresholds locally (r
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.