Evidence map›Paper›PMID 30178087›Full record

ReviewCurrent psychiatry reports2018

The Neuropeptide Hormone Oxytocin in Eating Disorders.

Franziska Plessow, Kamryn T Eddy, Elizabeth A Lawson

Open access · greenAbstract readReview
In one paragraph

Review in Current psychiatry reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Nutritional state-dependent changes in subcortical limbic structures in anorexia nervosa are linked to leptin, ghrelin, and neurofilament light.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Oxytocin: A Potential Therapeutic for Obesity.Journal of obesity & metabolic syndrome · 2021
    Review
  13. Oxytocin Pathway Gene (Frontiers in psychiatry · 2021
    Article
  14. Review
  15. Disrupted Oxytocin-Appetite Signaling in Females With Anorexia Nervosa.The Journal of clinical endocrinology and metabolism · 2019
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Franziska PlessowNeuroendocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, 55 Fruit Street BUL457, Boston, MA, 02114, USA. fplessow@mgh.harvard.edu.
Kamryn T EddyEating Disorders Clinical and Research Program, Massachusetts General Hospital and Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Elizabeth A LawsonNeuroendocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, 55 Fruit Street BUL457, Boston, MA, 02114, USA. ealawson@partners.org.
Harvard University · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Homeostatic and Hedonic Food Motivation Underlying Eating Disorder TrajectoriesR01MH103402 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, LAWSON, ELIZABETH AUSTEN · 2014 to 2018
$3.7M
Neurobiological and Behavioral Risk Mechanisms of Youth Avoidant/Restrictive Eating TrajectoriesR01MH108595 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN, MICALI, NADIA · 2016 to 2020
$3.4M
Oxytocin and Weight Loss in HumansR01DK109932 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN · 2017 to 2020
$2.7M
NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK109932NIMH NIH HHS R01 MH103402NIMH NIH HHS R01 MH108595
6 · The paper itself

Abstract

purpose of reviewThe neurohormone oxytocin (OXT) impacts food intake as well as cognitive, emotional, and social functioning-all of which are central to eating disorder (ED) pathology across the weight spectrum. Here, we review findings on endogenous OXT levels and their relationship to ED pathology, the impact of exogenous OXT on mechanisms that drive ED presentation and chronicity, and the potential role of genetic predispositions in the OXT-ED link. RECENT

findingsCurrent findings suggest a role of the OXT system in the pathophysiology of anorexia nervosa. In individuals with bulimia nervosa, endogenous OXT levels were comparable to those of healthy controls, and exogenous OXT reduced food intake. Studies in other ED are lacking. However, genetic studies suggest a broad role of the OXT system in influencing ED pathology. Highlighting findings on why OXT represents a potential biomarker of and treatment target for ED, we advocate for a systematic research approach spanning the entire ED spectrum.

Indexed as

Anorexia NervosaBody WeightBulimia NervosaFeeding and Eating DisordersHumansNeuropeptidesOxytocinNeuropeptidesOxytocinAnorexia nervosaBinge eatingBulimia nervosaEating disordersFood intakeOxytocin

Identifiers

PMID30178087
PMCPMC6903388
OpenAlexW2889907527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.