Evidence map›Paper›PMID 30178071›Full record

Observational studyWiener klinische Wochenschrift2018

Do acute coronary events affect lipid management and cholesterol goal attainment in Germany? : Results from the Dyslipidemia International study II.

Anselm K Gitt, Johannes Rieber, Rainer Hambrecht, Johannes Brachmann, Kristof Graf, Martin Horack, Barbara Karmann, Ami Vyas, Dominik Lautsch, Baishali Ambegaonkar and 1 more

Full text readObservational Study
In one paragraph

Observational study in Wiener klinische Wochenschrift, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anselm K GittHerzzentrum Ludwigshafen, Ludwigshafen, Germany. GittA@klilu.de.
Johannes RieberKlinikum Bogenhausen, Munich, Germany.
Rainer HambrechtKlinikum Links der Weser, Bremen, Germany.
Johannes BrachmannKlinikum Coburg, Coburg, Germany.
Kristof GrafJüdisches Krankenhaus Berlin, Berlin, Germany.
Martin HorackStiftung IHF-Institut für Herzinfarktforschung Ludwigshafen, Bremser Str. 79, 67117, Ludwigshafen, Germany.
Barbara KarmannMSD SHARP & DOHME GmbH, Haar, Germany.
Ami VyasSchool of Public Health, Department of Epidemiology, Rutgers University, Piscataway, NJ, USA.
Dominik LautschMerck & Co., Inc., Kenilworth, NJ, USA.
Baishali AmbegaonkarMerck & Co., Inc., Kenilworth, NJ, USA.
Philippe BrudiMerck & Co., Inc., Kenilworth, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo document utilization of lipid-lowering therapy, attainment of low-density lipoprotein cholesterol target values, and cardiovascular outcomes in patients hospitalized for acute coronary syndrome in Germany.

methodsThe Dyslipidemia International Study II was a multicenter, observational study of the prevalence of dyslipidemia and lipid target value attainment in patients surviving any acute coronary syndrome event. Among patients on lipid-lowering therapy for ≥3 months, use of lipid-lowering therapy and lipid profiles were assessed at admission and again at 120 ± 15 days after admission (the follow-up time point). Multivariate logistic regression was used to identify variables predictive of low-density lipoprotein cholesterol target value attainment in patients using lipid-lowering therapy.

resultsA total of 461 patients hospitalized for acute coronary syndrome were identified, 270 (58.6%) of whom were on lipid-lowering therapy at admission. Among patients on lipid-lowering therapy, 90.7% and 85.9% were receiving statin monotherapy at admission and follow-up, respectively. Mean (SD) low-density lipoprotein cholesterol levels in patients on lipid-lowering therapy were 101 (40) mg/dl and 95 (30) mg/dl at admission and follow-up, respectively. In patients with data at both admission and follow-up (n = 61), low-density lipoprotein cholesterol target value attainment rates were the same (19.7%) at both time points. Smoking was associated with a 77% lower likelihood of attaining the low-density lipoprotein cholesterol target value.

conclusionHospitalization for an acute event does not greatly alter lipid management in acute coronary syndrome patients in Germany. Both lipid-lowering therapy doses and rates of low-density lipoprotein cholesterol target value attainment remained essentially the same several months after the event.

Indexed as

Diabetes Mellitus, Type 2DyslipidemiasHydroxymethylglutaryl-CoA Reductase InhibitorsAgedCholesterolFemaleGermanyGoalsHumansLipidsMaleMiddle AgedTreatment OutcomeCholesterolHydroxymethylglutaryl-CoA Reductase InhibitorsLipidsAcute coronary syndromeCholesterolDyslipidemiasLDLMyocardial infarction

Identifiers

PMID30178071
PMCPMC6290720

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