ArticleJAMA pediatrics2018
Association of Prenatal Maternal Depression and Anxiety Symptoms With Infant White Matter Microstructure.
Article in JAMA pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Socioeconomic factors and sex effects of postpartum maternal depression on offspring internalizing symptoms: a systematic review and meta-analysis.BMC medicine · 2025Pooled it
- Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies.Brain imaging and behavior · 2023Pooled it
- Mindful awareness as a mechanism of change for natural childbirth in pregnant women with high fear of childbirth: a randomised controlled trial.BMC pregnancy and childbirth · 2022Trial
- Effects of prenatal mindfulness-based childbirth education on child-bearers' trajectories of distress: a randomized control trial.BMC pregnancy and childbirth · 2020Trial
- Postnatal distress, neonatal cerebellar myelination and neurodevelopmental outcomes at 18 months.Molecular psychiatry · 2026Article
- Beyond the Wiring: White Matter as a Dynamic Regulator of Brain Function and Disease.Neuroscience bulletin · 2026Review
- Association of prenatal depression and anxiety with cortical development and behavioral outcomes in 8-year-old children.Journal of affective disorders · 2026Article
- Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics.Pediatric research · 2026Article
- Prenatal maternal psychological distress is associated with neurodevelopmental outcomes in toddlers with congenital heart disease.Pediatric research · 2026Article
- Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure.Psychological medicine · 2026Article
- Poverty and caregiver mental health are related to infant and toddler resting-state brain networks: insights from fNIRS.Neurophotonics · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Anxiety and depressive disorders in the offspring of mothers with perinatal depressive disorders.European child & adolescent psychiatry · 2025Article
- In vivo mapping of infant brain microstructure with neurite orientation dispersion and density imaging.Brain structure & function · 2025Review
- Maternal Depressive Symptoms and Risk for Childhood Depression: Role of Executive Functions.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Observational
- Neutrophil infiltration and microglial shifts in sepsis induced preterm brain injury: pathological insights.Acta neuropathologica communications · 2025Article
- Brain white matter development in 8-year-old children is associated with maternal mental health during pregnancy.Frontiers in human neuroscience · 2025Article
- Prenatal Antidepressant Exposure and the Developing Brain: A Review of Neuroimaging Findings.Current topics in behavioral neurosciences · 2025Review
- Gray matter based spatial statistics framework in the 1-month brain: insights into gray matter microstructure in infancy.Brain structure & function · 2024Article
- Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development.Pediatric research · 2024Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
Importance: Maternal depression and anxiety can have deleterious and lifelong consequences on child development. However, many aspects of the association of early brain development with maternal symptoms remain unclear. Understanding the timing of potential neurobiological alterations holds inherent value for the development and evaluation of future therapies and interventions. Objective: To examine the association between exposure to prenatal maternal depression and anxiety symptoms and offspring white matter microstructure at 1 month of age. Design, Setting, and Participants: This cohort study of 101 mother-infant dyads used a composite of depression and anxiety symptoms measured in mothers during the third trimester of pregnancy and measures of white matter microstructure characterized in the mothers' 1-month offspring using diffusion tensor imaging and neurite orientation dispersion and density imaging performed from October 1, 2014, to November 30, 2016. Magnetic resonance imaging was performed at an academic research facility during natural, nonsedated sleep. Main Outcomes and Measures: Brain mapping algorithms and statistical models were used to evaluate the association between maternal depression and anxiety and 1-month infant white matter microstructure as measured by diffusion tensor imaging and neurite orientation dispersion and density imaging findings. Results: In the 101 mother-infant dyads (mean [SD] age of mothers, 33.22 [3.99] years; mean age of infants at magnetic resonance imaging, 33.07 days [range, 18-50 days]; 92 white mothers [91.1%]; 53 male infants [52.5%]), lower 1-month white matter microstructure (decreased neurite density and increased mean, radial, and axial diffusivity) was associated in right frontal white matter microstructure with higher prenatal maternal symptoms of depression and anxiety. Significant sex × symptom interactions with measures of white matter microstructure were also observed, suggesting that white matter development may be differentially sensitive to maternal depression and anxiety symptoms in males and females during the prenatal period. Conclusions and Relevance: These data highlight the importance of the prenatal period to early brain development and suggest that the underlying white matter microstructure is associated with the continuum of prenatal maternal depression and anxiety symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.