Evidence map›Paper›PMID 30177804›Full record

ArticleNature ecology & evolution2018

The evolutionary landscape of colorectal tumorigenesis.

William Cross, Michal Kovac, Ville Mustonen, Daniel Temko, Hayley Davis, Ann-Marie Baker, Sujata Biswas, Roland Arnold, Laura Chegwidden, Chandler Gatenbee and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature ecology & evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed.

  1. Article
  2. Review
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  9. Article
  10. Article
  11. Article
  12. Article
  13. Signaling pathways and targeted interventions for precancers.Signal transduction and targeted therapy · 2026
    Review
  14. Review
  15. Article
  16. Polyclonal origins of human premalignant colorectal lesions.bioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Evolutionary paths towards metastasis.Nature reviews. Cancer · 2025
    Review
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

William CrossEvolution and Cancer Laboratory, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Michal KovacMolecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Ville MustonenOrganismal and Evolutionary Biology Research Programme, Department of Computer Science, Institute of Biotechnology, Helsinki Institute for Information Technology HIIT, University of Helsinki, Helsinki, Finland.
Daniel TemkoEvolution and Cancer Laboratory, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-0165-292X
Hayley DavisGastrointestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Ann-Marie BakerEvolution and Cancer Laboratory, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Sujata BiswasGastrointestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Roland ArnoldCancer Bioinfomatics Group, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Laura ChegwiddenGastrointestinal Cancer Genetics Laboratory, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Chandler GatenbeeIntegrated Mathematical Oncology Department, Moffitt Comprehensive Cancer Centre, Tampa, FL, USA.
Alexander R AndersonIntegrated Mathematical Oncology Department, Moffitt Comprehensive Cancer Centre, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-2536-4383
Viktor H KoelzerMolecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-9206-4885
Pierre MartinezEvolution and Cancer Laboratory, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Xiaowei JiangCancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-6030-1249
Enric DomingoMolecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-4390-8767
Dan J WoodcockBig Data Institute, University of Oxford, Oxford, UK.
Yun FengMolecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Monika KovacovaInstitute of Mathematics and Physics, Faculty of Mechanical Engineering, Slovak University of Technology in Bratislava, Bratislava, Slovakia.
Tim MaughanDepartment of Oncology, University of Oxford, Oxford, UK.
S:CORT Consortium
Marnix JansenDepartment of Research Pathology, Cancer Institute, University College London, London, UK.
Manuel Rodriguez-JustoDepartment of Research Pathology, Cancer Institute, University College London, London, UK.
Shazad AshrafDepartment of Surgery, University Hospitals Birmingham, Birmingham, UK.
Richard GuyDepartment of Colorectal Surgery, Cancer Centre, Churchill Hospital, Oxford University Hospital NHS Foundation Trust, Oxford, UK.
Christopher CunninghamDepartment of Colorectal Surgery, Cancer Centre, Churchill Hospital, Oxford University Hospital NHS Foundation Trust, Oxford, UK.
James E EastTranslational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK.
David C WedgeBig Data Institute, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-7572-3196
Lai Mun WangLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Claire PallesGastrointestinal Cancer Genetics Laboratory, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Karl HeinimannInstitute for Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Andrea SottorivaEvolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0001-6709-9533
Simon J LeedhamGastrointestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Trevor A GrahamEvolution and Cancer Laboratory, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. t.graham@qmul.ac.uk.ORCID http://orcid.org/0000-0001-9582-1597
Ian P M TomlinsonCancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. i.tomlinson@bham.ac.uk.ORCID http://orcid.org/0000-0003-3037-1470

Funding

Cancer Research UK 16459Cancer Research UK 16581Cancer Research UK 19590Cancer Research UK 19771Cancer Research UK 22909Cancer Research UK 23969Cancer Research UK 24430Cancer Research UK 25350Cancer Research UK A16459Cancer Research UK A19771European Research Council 340560Medical Research Council MC_UU_12023/20Medical Research Council MR/K000063/1Medical Research Council MR/L016508/1Medical Research Council MR/M009157/1Medical Research Council MR/M016587/1Wellcome Trust 202778/Z/16/ZWellcome Trust 206314/Z/17/Z
6 · The paper itself

Abstract

The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, we investigate the evolutionary fitness landscape occupied by these neoplasms. Unlike carcinomas, advanced adenomas frequently harbour sub-clonal driver mutations-considered to be functionally important in the carcinogenic process-that have not swept to fixation, and have relatively high genetic heterogeneity. Carcinomas are distinguished from adenomas by widespread aneusomies that are usually clonal and often accrue in a 'punctuated' fashion. We conclude that adenomas evolve across an undulating fitness landscape, whereas carcinomas occupy a sharper fitness peak, probably owing to stabilizing selection.

Indexed as

Evolution, MolecularMutationAdenomaCarcinogenesisCarcinomaColorectal NeoplasmsHumansModels, Biological

Identifiers

PMID30177804
PMCPMC6152905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.