Evidence map›Paper›PMID 30177704›Full record

ArticleNature communications2018

Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABA

Jan M Schulz, Frederic Knoflach, Maria-Clemencia Hernandez, Josef Bischofberger

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 125 citations in OpenAlex.

  1. Article
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  10. RO4938581, a GABAMolecular psychiatry · 2026
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  19. Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jan M SchulzDepartment of Biomedicine, University of Basel, Pestalozzistr. 20, CH-4056, Basel, Switzerland.
Frederic KnoflachPharma Research and Early Development, Discovery Neuroscience Department, F. Hoffmann-La Roche Ltd, CH-4070, Basel, Switzerland.
Maria-Clemencia HernandezPharma Research and Early Development, Discovery Neuroscience Department, F. Hoffmann-La Roche Ltd, CH-4070, Basel, Switzerland.
Josef BischofbergerDepartment of Biomedicine, University of Basel, Pestalozzistr. 20, CH-4056, Basel, Switzerland. Josef.Bischofberger@unibas.ch.ORCID http://orcid.org/0000-0002-4006-1663
Roche (Switzerland) · CHUniversity of Basel · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 31003A_176321
6 · The paper itself

Abstract

Dendrite-targeting GABAergic interneurons powerfully control postsynaptic integration, synaptic plasticity, and learning. However, the mechanisms underlying the efficient GABAergic control of dendritic electrogenesis are not well understood. Using subtype-selective blockers for GABA

Indexed as

Inhibitory Postsynaptic PotentialsAction PotentialsAnimalsCA1 Region, HippocampalDendritesInterneuronsMiceMice, TransgenicParvalbuminsPatch-Clamp TechniquesPyramidal CellsReceptors, GABA-AReceptors, N-Methyl-D-AspartateSynapsesSynaptic TransmissionGabra5 protein, mouseParvalbuminsReceptors, GABA-AReceptors, N-Methyl-D-Aspartate

Identifiers

PMID30177704
PMCPMC6120902
OpenAlexW2889189141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.