ArticleNature communications2018
Social environment mediates cancer progression in Drosophila.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ageing effects of social environments in 'non-social' insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Pooled it
- Beyond the mouse: 3R-guided alternative animal models transforming cancer research.Molecular cancer · 2026Review
- Oncogenic stress alters predator-prey interactions between a globally invasive and a native planaria species.iScience · 2025Article
- Exploring the versatility ofFly · 2025Review
- Article
- The complex effects of modern oncogenic environments on the fitness, evolution and conservation of wildlife species.Evolutionary applications · 2024Article
- Male manipulation impinges on social-dependent tumor suppression in Drosophila melanogaster females.Scientific reports · 2024Article
- Behavioural ecology meets oncology: quantifying the recovery of animal behaviour to a transient exposure to a cancer risk factor.Proceedings. Biological sciences · 2024Article
- On the possibility of engineering social evolution in microfluidic environments.Biophysical journal · 2024Article
- Social buffer or avoidance depends on the similarity of stress between queen ants.Current zoology · 2023Article
- Both age and social environment shape the phenotype of ant workers.Scientific reports · 2023Article
- Article
- Survey on the Past Decade of Technology in Animal Enrichment: A Scoping Review.Animals : an open access journal from MDPI · 2022Article
- Social perception of young adults prolongs the lifespan of aged Drosophila.NPJ aging and mechanisms of disease · 2021Article
- Chronically lonely flies overeat and lose sleep.Nature · 2021Article
- Spatial and Social Behavior of Single and Coupled Individuals of Both Sexes during COVID-19 Lockdown Regime in Russia.International journal of environmental research and public health · 2021Article
- Tiny Drosophila makes giant strides in cancer research.Cancer science · 2021Review
- Using Flies to Understand Social Networks.Frontiers in neural circuits · 2021Review
- Behavior Individuality: A Focus onFrontiers in physiology · 2021Review
- Infectious disease and sickness behaviour: tumour progression affects interaction patterns and social network structure in wild Tasmanian devils.Proceedings. Biological sciences · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of oncogenic phenomena on the ecology and evolution of animal species is becoming an important research topic. Similar to host-pathogen interactions, cancer negatively affects host fitness, which should lead to the selection of host control mechanisms, including behavioral traits that best minimize the proliferation of malignant cells. Social behavior is suggested to influence tumor progression. While the ecological benefits of sociality in gregarious species are widely acknowledged, only limited data are available on the role of the social environment on cancer progression. Here, we exposed adult Drosophila, with colorectal-like tumors, to different social environments. We show how subtle variations in social structure have dramatic effects on the progression of tumor growth. Finally, we reveal that flies can discriminate between individuals at different stages of tumor development and selectively choose their social environment accordingly. Our study demonstrates the reciprocal links between cancer and social interactions and how sociality may impact health and fitness in animals and its potential implications for disease ecology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.