ArticleNature communications2018
Dehydrogenative reagent-free annulation of alkenes with diols for the synthesis of saturated O-heterocycles.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 145 citations in OpenAlex.
- Metal-Free Electrochemical Construction of Oxygen Heterocycles.Accounts of chemical research · 2026Article
- Trisubstituted Alkenes as Valuable Building Blocks.Molecules (Basel, Switzerland) · 2025Review
- Metal-free electrochemical dihydroxylation of unactivated alkenes.Nature communications · 2023Article
- Electrochemical oxidative difunctionalization of diazo compounds with two different nucleophiles.Nature communications · 2023Article
- Nickel-catalyzed switchable asymmetric electrochemical functionalization of alkenes.Science advances · 2022Article
- Oxetan-3-ols as 1,2-bis-Electrophiles in a Brønsted-Acid-Catalyzed Synthesis of 1,4-Dioxanes.Organic letters · 2022Article
- Synthetic Molecular Photoelectrochemistry: New Frontiers in Synthetic Applications, Mechanistic Insights and Scalability.Angewandte Chemie (International ed. in English) · 2022Review
- Electrochemical organic reactions: A tutorial review.Frontiers in chemistry · 2022Review
- Redox-active molecules as organocatalysts for selective oxidative transformations - an unperceived organocatalysis field.Beilstein journal of organic chemistry · 2022Article
- Electrochemical C-C bond cleavage of cyclopropanes towards the synthesis of 1,3-difunctionalized molecules.Nature communications · 2021Article
- Electrochemically driven stereoselective approach toChemical science · 2021Article
- Electroreductive Carbofunctionalization of Alkenes with Alkyl Bromides via a Radical-Polar Crossover Mechanism.Journal of the American Chemical Society · 2020Article
- Electrophotocatalytic Undirected C-H Trifluoromethylations of (Het)Arenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Electrooxidation enables highly regioselective dearomative annulation of indole and benzofuran derivatives.Nature communications · 2020Article
- Practical and stereoselective electrocatalytic 1,2-diamination of alkenes.Nature communications · 2019Article
- Electrochemical fluoromethylation triggered lactonizations of alkenes under semi-aqueous conditions.Chemical science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dehydrogenative annulation reactions are among the most straightforward and efficient approach for the preparation of cyclic structures. However, the applications of this strategy for the synthesis of saturated heterocycles have been rare. In addition, reported dehydrogenative bond-forming reactions commonly employ stoichiometric chemical oxidants, the use of which reduces the sustainability of the synthesis and brings safety and environmental issues. Herein, we report an organocatalyzed electrochemical dehydrogenative annulation reaction of alkenes with 1,2- and 1,3-diols for the synthesis of 1,4-dioxane and 1,4-dioxepane derivatives. The combination of electrochemistry and redox catalysis using an organic catalyst allows the electrosynthesis to proceed under transition metal- and oxidizing reagent-free conditions. In addition, the electrolytic method has a broad substrate scope and is compatible with many common functional groups, providing an efficient and straightforward access to functionalized 1,4-dioxane and 1,4-dioxepane products with diverse substitution patterns.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.