ArticlePediatrics2018
Variations in Neonatal Antibiotic Use.
Article in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Trial
- Remote Stewardship for Medically Underserved Nurseries: A Stepped-Wedge, Cluster Randomized Study.Pediatrics · 2022Trial
- Antimicrobial Use in U.S. Hospitals: Comparison of 2015 and 2023 Prevalence Surveys.Open forum infectious diseases · 2026Article
- Impact of Early-Life Antibiotic Exposure on Gut Microbiome and Vaccine Immunogenicity in Infants: A Narrative Review.Journal of clinical medicine · 2026Review
- Multimodal Implementations to Reduce Neonatal Ventilator-Associated Pneumonia and Colistin Use: An Interrupted Time Series.Antibiotics (Basel, Switzerland) · 2025Article
- Neonatology: First Exposure to Antibiotics from the Ethical Perspective of Parents, Physicians, and Regulators.Antibiotics (Basel, Switzerland) · 2025Article
- Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe).BMC pediatrics · 2025Article
- 28 NICUs participating in a quality improvement collaborative targeting early-onset sepsis antibiotic use.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Decreasing Antibiotic Use in a Community Neonatal Intensive Care Unit: A Quality Improvement Initiative.American journal of perinatology · 2024Article
- Antibiotic Use in a Neonatal Intensive Care Unit Practicing Integrative Medicine-A Retrospective Analysis.Journal of integrative and complementary medicine · 2024Observational
- Variation in antibiotic consumption in very preterm infants-a 10 year population-based study.The Journal of antimicrobial chemotherapy · 2024Article
- Less is more: Antibiotics at the beginning of life.Nature communications · 2023Review
- Antibiotic Resistance and Biofilm Infections in the NICUs and Methods to Combat It.Antibiotics (Basel, Switzerland) · 2023Review
- Vignette Research Methodology: An Essential Tool for Quality Improvement Collaboratives.Healthcare (Basel, Switzerland) · 2022Article
- Association Between Antibiotic Overexposure and Adverse Outcomes in Very-Low-Birth-Weight Infants Without Culture-Proven Sepsis or Necrotizing Enterocolitis: A Multicenter Prospective Study.Indian journal of pediatrics · 2022Article
- Managing antibiotics wisely in a neonatal intensive care unit in a low resource setting.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- The resistance within: Antibiotic disruption of the gut microbiome and resistome dynamics in infancy.Cell host & microbe · 2022Review
- Reducing Early Antibiotic Use: A Quality Improvement Initiative in a Level III Neonatal Intensive Care Unit.Frontiers in pediatrics · 2022Article
- Newborns with Bloody Stools-At the Crossroad between Efficient Management of Necrotizing Enterocolitis and Antibiotic Stewardship.Antibiotics (Basel, Switzerland) · 2021Article
- Prescription of Aminoglycosides in 23 French Neonatal Intensive Care Units.Antibiotics (Basel, Switzerland) · 2021Article
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Authors and funding
8 authors.
Funding
Abstract
objectivesWe sought to identify whether and how the NICU antibiotic use rate (AUR), clinical correlates, and practice variation changed between 2013 and 2016 and attempted to identify AUR ranges that are consistent with objectively determined bacterial and/or fungal disease burdens.
methodsIn a retrospective cohort study of >54 000 neonates annually at >130 California NICUs from 2013 to 2016, we computed nonparametric linear correlation and compared AURs among years using a 2-sample test of proportions. We stratified by level of NICU care and participation in externally organized stewardship efforts.
resultsBy 2016, the overall AUR declined 21.9% (95% confidence interval [CI] 21.9%-22.0%), reflecting 42 960 fewer antibiotic days. Among NICUs in externally organized antibiotic stewardship efforts, the AUR declined 28.7% (95% CI 28.6%-28.8%) compared with 16.2% (95% CI 16.1%-16.2%) among others. The intermediate NICU AUR range narrowed, but the distribution of values did not shift toward lower values as it did for other levels of care. The 2016 AUR correlated neither with proven infection nor necrotizing enterocolitis. The 2016 regional NICU AUR correlated with surgical volume (ρ = 0.53;
conclusionsUnexplained antibiotic use has declined but continues. Currently measured clinical correlates generally do not help explain AUR values that are above the lowest quartile cutpoint of 14.4%.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.